Diosmectite

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Diosmectite
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Diosmectite powder
Clinical data
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Identifiers
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Chemical and physical data
Formula(Na-Ca)0.33-(Al-Mg)2-Si4-O10-(O-H)2·(H2O)2
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Diosmectite (brand names Smecta, Smecdral) is a natural silicate of aluminium and magnesium used as an intestinal adsorbent in the treatment of several gastrointestinal diseases, including infectious and non-infectious acute and chronic diarrhoea, including irritable bowel syndrome diarrhea subtype. Other uses include: chronic diarrhea caused by radiation-induced, chemotherapy-induced, and HIV/AIDS-associated chronic diarrhea.[1]

It is insoluble in water. It is usually taken orally as a suspension in warm water. In the field of geology, it is more commonly known as montmorillonite. Diosmectite is a contraction of "dioctahedral smectite".

Mechanism of action

Its effectiveness in improving stool consistency is the result of its alleged ability to absorb bacteria, viruses and toxins as well as strengthening the intestinal mucus barrier to reduce luminal antigens passing through the mucus barrier which in turn helps to reduce inflammation.[1]

Diosmectite may be a useful additive in the treatment of acute childhood diarrhoea. As evidence is of ‘low quality’, future research is needed with higher quality designs before any firm recommendations can be made.[2]

See also

References

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  1. ^ a b Page Module:Citation/CS1/styles.css has no content.Lee KJ (October 2015). "Pharmacologic Agents for Chronic Diarrhea". Intestinal Research. 13 (4): 306–312. doi:10.5217/ir.2015.13.4.306. PMC 4641856. PMID 26576135.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Das RR, Sankar J, Naik SS (July 2015). "Efficacy and safety of diosmectite in acute childhood diarrhoea: a meta-analysis". Archives of Disease in Childhood. 100 (7): 704–712. doi:10.1136/archdischild-2014-307632. PMID 25784748. S2CID 20092600.

Further reading

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  • Page Module:Citation/CS1/styles.css has no content.Santantonio M, Colella M, Fiorica F, Pratissoli S, Stefanelli A, Falchi AM, et al. (December 2000). "Diosmectite (DIOSMECTAL) in preventive anti-diarrheic therapy in patients subjected to pelvic radiation". Minerva Gastroenterologica e Dietologica. 46 (4): 225–230. PMID 16501441.

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