FOXP4
Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.[1]
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[1] It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research.[2][3]
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: FOXP4 forkhead box P4".
- ^ Page Module:Citation/CS1/styles.css has no content.Ledford H (July 2023). "Gene linked to long COVID found in analysis of thousands of patients". Nature. 619 (7970): 445. Bibcode:2023Natur.619..445L. doi:10.1038/d41586-023-02269-2. PMID 37433943. S2CID 259831412.
- ^ Page Module:Citation/CS1/styles.css has no content.Lammi V, Nakanishi T, Jones SE, Andrews SJ, Karjalainen J, Cortés B, et al. (June 2025). "Genome-wide association study of long COVID". Nature Genetics. 57 (6): 1402–1417. doi:10.1038/s41588-025-02100-w. PMC 12165857. PMID 40399555.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Katoh M, Katoh M (2005). "Human FOX gene family (Review)". International Journal of Oncology. 25 (5): 1495–1500. doi:10.3892/ijo.25.5.1495. PMID 15492844.
- Page Module:Citation/CS1/styles.css has no content.Lu MM, Li S, Yang H, Morrisey EE (2003). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Gene Expression Patterns. 2 (3–4): 223–228. doi:10.1016/S1567-133X(02)00058-3. PMID 12617805. (Retracted, see Script error: No such module "CS1 identifiers".)
- Page Module:Citation/CS1/styles.css has no content.Teufel A, Wong EA, Mukhopadhyay M, Malik N, Westphal H (June 2003). "FoxP4, a novel forkhead transcription factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1627 (2–3): 147–152. doi:10.1016/S0167-4781(03)00074-5. PMID 12818433.
- Page Module:Citation/CS1/styles.css has no content.Lu MM, Li S, Yang H, Morrisey EE (2002). "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Mechanisms of Development. 119 (Suppl 1): S197–202. doi:10.1016/S0925-4773(03)00116-3. PMID 14516685. S2CID 935988.
- Page Module:Citation/CS1/styles.css has no content.Li S, Weidenfeld J, Morrisey EE (2004). "Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions". Molecular and Cellular Biology. 24 (2): 809–822. doi:10.1128/MCB.24.2.809-822.2004. PMC 343786. PMID 14701752.
- Page Module:Citation/CS1/styles.css has no content.Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, et al. (September 2006). "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation. 114 (12): 1269–1276. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.
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