Fendiline

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Fendiline
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Clinical data
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Identifiers
  • 3,3-diphenyl-N-(1-phenylethyl)propan-1-amine
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Chemical and physical data
FormulaC23H25N
Molar mass315.460 g·mol−1
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  • CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3
  • InChI=1S/C23H25N/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16,19,23-24H,17-18H2,1H3 ☒N
  • Key:NMKSAYKQLCHXDK-UHFFFAOYSA-N ☒N
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Fendiline is a nonselective calcium channel blocker and coronary vasodilator, originally developed for its anti-anginal and antiarrhythmic properties in the management of coronary heart disease.[1][2][3]

By inhibiting the influx of calcium ions into cardiac and vascular smooth muscle cells, fendiline promotes vasodilation, particularly of the coronary arteries, thereby increasing blood flow to the heart muscle, alleviating ischemia, and reducing chest pain associated with angina.[2] Although its clinical use has become limited due to the availability of alternative treatments and its relatively slow onset of action, fendiline remains notable for its long half-life, lack of tolerance development, and demonstrated efficacy in improving exercise tolerance and reducing the frequency of angina attacks in placebo-controlled trials.[2]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content."Fendiline". DrugBank.
  2. ^ a b c Page Module:Citation/CS1/styles.css has no content.Bayer R, Mannhold R (1987). "Fendiline: a review of its basic pharmacological and clinical properties". Pharmatherapeutica. 5 (2): 103–136. OCLC 115670794. PMID 3310016.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Scultéty S, Tamáskovits E (1991). "Effect of Ca2+ antagonists on isolated rabbit detrusor muscle". Acta Physiologica Hungarica. 77 (3–4): 269–278. PMID 1755331.

Further reading

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