GDI1
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Rab GDP dissociation inhibitor alpha is a protein that in humans is encoded by the GDI1 gene.[1][2]
Function
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific intellectual disability.[3]
Rab GTPases cycles between the cytosolic compartment, where it is bound to a protein called GDI (GDP Dissociation Inhibitor), and the membrane, where it interacts with a receptor, a nucleotide exchange factor, a GAP (GTPase Activating Protein) and probably other factors that link it to the appropriate SNARE. GDI is non-specific with respect to the rab it binds. However, the exchanger, receptor and GAP, are rab specific.
Interactions
GDI1 has been shown to interact with CDC42.[4]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Bächner D, Sedlacek Z, Korn B, Hameister H, Poustka A (Sep 1995). "Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport". Hum. Mol. Genet. 4 (4): 701–8. doi:10.1093/hmg/4.4.701. PMID 7543319.
- ^ Page Module:Citation/CS1/styles.css has no content.Sedlacek Z, Konecki DS, Korn B, Klauck SM, Poustka A (October 1994). "Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI)". Mammalian Genome. 5 (10): 633–9. doi:10.1007/BF00411459. PMID 7849400. S2CID 6441432.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: GDI1 GDP dissociation inhibitor 1".
- ^ Page Module:Citation/CS1/styles.css has no content.Gibson RM, Wilson-Delfosse AL (Oct 2001). "RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells". Biochem. J. 359 (Pt 2): 285–94. doi:10.1042/0264-6021:3590285. PMC 1222146. PMID 11583574.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
- Page Module:Citation/CS1/styles.css has no content.Matsui Y, Kikuchi A, Araki S, Hata Y, Kondo J, Teranishi Y, Takai Y (1990). "Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein". Mol. Cell. Biol. 10 (8): 4116–22. doi:10.1128/mcb.10.8.4116. PMC 360933. PMID 2115118.
- Page Module:Citation/CS1/styles.css has no content.Shisheva A, Südhof TC, Czech MP (1994). "Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle". Mol. Cell. Biol. 14 (5): 3459–68. doi:10.1128/mcb.14.5.3459. PMC 358710. PMID 7513052.
- Page Module:Citation/CS1/styles.css has no content.Nishimura N, Goji J, Nakamura H, Orita S, Takai Y, Sano K (1995). "Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens". Cancer Res. 55 (22): 5445–50. PMID 7585614.
- Page Module:Citation/CS1/styles.css has no content.Shapiro AD, Pfeffer SR (1995). "Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides". J. Biol. Chem. 270 (19): 11085–90. doi:10.1074/jbc.270.19.11085. PMID 7744738.
- Page Module:Citation/CS1/styles.css has no content.Beranger F, Cadwallader K, Porfiri E, Powers S, Evans T, de Gunzburg J, Hancock JF (1994). "Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase". J. Biol. Chem. 269 (18): 13637–43. doi:10.1016/S0021-9258(17)36877-1. PMID 8175798.
- Page Module:Citation/CS1/styles.css has no content.Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A (1993). "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection". Hum. Mol. Genet. 2 (11): 1865–9. doi:10.1093/hmg/2.11.1865. PMID 8281148.
- Page Module:Citation/CS1/styles.css has no content.Hancock JF, Hall A (1993). "A novel role for RhoGDI as an inhibitor of GAP proteins". EMBO J. 12 (5): 1915–21. doi:10.1002/j.1460-2075.1993.tb05840.x. PMC 413412. PMID 8491184.
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- Page Module:Citation/CS1/styles.css has no content.Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells". Biochem. J. 318 (3): 1007–14. doi:10.1042/bj3181007. PMC 1217717. PMID 8836150.
- Page Module:Citation/CS1/styles.css has no content.des Portes V, Billuart P, Carrié A, Bachner L, Bienvenu T, Vinet MC, Beldjord C, Ponsot G, Kahn A, Boué J, Chelly J (1997). "A gene for dominant nonspecific X-linked mental retardation is located in Xq28". Am. J. Hum. Genet. 60 (4): 903–9. PMC 1712488. PMID 9106537.
- Page Module:Citation/CS1/styles.css has no content.Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. Bibcode:1998FEBSL.422..269G. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022. S2CID 10817327.
- Page Module:Citation/CS1/styles.css has no content.D'Adamo P, Menegon A, Lo Nigro C, Grasso M, Gulisano M, Tamanini F, Bienvenu T, Gedeon AK, Oostra B, Wu SK, Tandon A, Valtorta F, Balch WE, Chelly J, Toniolo D (1998). "Mutations in GDI1 are responsible for X-linked non-specific mental retardation". Nat. Genet. 19 (2): 134–9. doi:10.1038/487. PMID 9620768. S2CID 21043350.
- Page Module:Citation/CS1/styles.css has no content.Bienvenu T, des Portes V, Saint Martin A, McDonell N, Billuart P, Carrié A, Vinet MC, Couvert P, Toniolo D, Ropers HH, Moraine C, van Bokhoven H, Fryns JP, Kahn A, Beldjord C, Chelly J (1998). "Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor". Hum. Mol. Genet. 7 (8): 1311–5. doi:10.1093/hmg/7.8.1311. PMID 9668174.
- Page Module:Citation/CS1/styles.css has no content.Wan M, Francke U (1998). "Evaluation of two X chromosomal candidate genes for Rett syndrome: glutamate dehydrogenase-2 (GLUD2) and rab GDP-dissociation inhibitor (GDI1)". Am. J. Med. Genet. 78 (2): 169–72. doi:10.1002/(SICI)1096-8628(19980630)78:2<169::AID-AJMG14>3.0.CO;2-L. PMID 9674910.
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