GLYCAM1
Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Glycosylation-dependent cell adhesion molecule-1 is a protein that is encoded by the GLYCAM1 gene. In humans, GLYCAM1 is a pseudogene while in many other mammals including mouse, it is a protein coding gene.
GLYCAM1 is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.[1][2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[3]
GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.[1]
References
Page Template:Reflist/styles.css has no content.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Imhof BA, Dunon D (1995). Leukocyte Migration and Adhesion. Advances in Immunology. Vol. 58. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9. ISBN 978-0-12-022458-6. PMID 7537936.
- ^ Page Module:Citation/CS1/styles.css has no content.Brustein M, Kraal G, Mebius RE, Watson SR (November 1992). "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. doi:10.1084/jem.176.5.1415. PMC 2119429. PMID 1383387.
- ^ Page Module:Citation/CS1/styles.css has no content.Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–960. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.
External links
- GlyCAM-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
