GNAL
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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.[1][2] Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.[3]
See also
- Second messenger system
- G protein-coupled receptor
- Heterotrimeric G protein
- Adenylyl cyclase
- Protein kinase A
- Olfactory receptors
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, et al. (May 1992). "Evolution of the mammalian G protein alpha subunit multigene family". Nature Genetics. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type".
- ^ Page Module:Citation/CS1/styles.css has no content.Zhuang X, Belluscio L, Hen R (August 2000). "G(olf)alpha mediates dopamine D1 receptor signaling". The Journal of Neuroscience. 20 (16) RC91. doi:10.1523/JNEUROSCI.20-16-j0001.2000. PMC 6772608. PMID 10924528.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Zigman JM, Westermark GT, LaMendola J, Boel E, Steiner DF (December 1993). "Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system". Endocrinology. 133 (6): 2508–2514. doi:10.1210/endo.133.6.8243272. PMID 8243272.
- Page Module:Citation/CS1/styles.css has no content.Astesano A, Regnauld K, Ferrand N, Gingras D, Bendayan M, Rosselin G, et al. (March 1999). "Cellular and subcellular expression of Golf/Gs and Gq/G11 alpha-subunits in rat pancreatic endocrine cells". The Journal of Histochemistry and Cytochemistry. 47 (3): 289–302. doi:10.1177/002215549904700303. PMID 10026232.
- Page Module:Citation/CS1/styles.css has no content.Vuoristo JT, Berrettini WH, Overhauser J, Prockop DJ, Ferraro TN, Ala-Kokko L (September 2000). "Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia". Molecular Psychiatry. 5 (5): 495–501. doi:10.1038/sj.mp.4000758. PMID 11032382. S2CID 23116111.
- Page Module:Citation/CS1/styles.css has no content.Zill P, Engel R, Baghai TC, Zwanzger P, Schüle C, Minov C, et al. (March 2002). "Analysis of polymorphisms in the olfactory G-protein Golf in major depression". Psychiatric Genetics. 12 (1): 17–22. doi:10.1097/00041444-200203000-00002. PMID 11901355. S2CID 22757545.
- Page Module:Citation/CS1/styles.css has no content.Régnauld K, Nguyen QD, Vakaet L, Bruyneel E, Launay JM, Endo T, et al. (June 2002). "G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells". Oncogene. 21 (25): 4020–4031. doi:10.1038/sj.onc.1205498. PMID 12037684. S2CID 23730354.
- Page Module:Citation/CS1/styles.css has no content.Zill P, Malitas PN, Bondy B, Engel R, Boufidou F, Behrens S, et al. (June 2003). "Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients". Psychiatric Genetics. 13 (2): 65–69. doi:10.1097/01.ypg.0000057881.80011.45. PMID 12782961. S2CID 20253173.
- Page Module:Citation/CS1/styles.css has no content.Corradi JP, Ravyn V, Robbins AK, Hagan KW, Peters MF, Bostwick R, et al. (November 2005). "Alternative transcripts and evidence of imprinting of GNAL on 18p11.2". Molecular Psychiatry. 10 (11): 1017–1025. doi:10.1038/sj.mp.4001713. PMID 16044173. S2CID 19513069.
- Page Module:Citation/CS1/styles.css has no content.Ravyn V, Bostwick JR (2006). "Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor". Journal of Receptor and Signal Transduction Research. 26 (4): 241–258. doi:10.1080/10799890600710592. PMID 16818375. S2CID 27231567.
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