GPR158
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Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),[1] is a protein that in humans is encoded by the GPR158 gene.[2]
Function
This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[3]
It is expressed at lower levels in other organs and shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[4]
Clinical significance
Role in mood regulation
GPR158 in the medial prefrontal cortex (mPFC) has been shown to regulate stress-induced depression in a mouse model of depression and has been found to be upregulated in post-mortem tissue samples from humans with major depressive disorder (MDD).[5]
Role in prostate cancer
The GPR158 gene is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation.[6]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA (March 2023). "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science. 379 (6639): 1352–1358. Bibcode:2023Sci...379.1352L. doi:10.1126/science.add7150. PMC 10751545. PMID 36996198. S2CID 257836784.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: GPR158 G protein-coupled receptor 158".
- ^ Page Module:Citation/CS1/styles.css has no content.Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
- ^ Page Module:Citation/CS1/styles.css has no content.Patel N, Itakura T, Gonzalez JM, Schwartz SG, Fini ME (2013). "GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role". PLOS ONE. 8 (2) e57843. Bibcode:2013PLoSO...857843P. doi:10.1371/journal.pone.0057843. PMC 3581496. PMID 23451275. Open access icon
- ^ Page Module:Citation/CS1/styles.css has no content.Sutton L, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JD, Renner KJ, Young Jr SM, Xu B, Kwon H, Martemyanov KA (2018). "Orphan receptor GPR158 controls stress-induced depression". eLife. 7. doi:10.7554/eLife.33273.001. PMC 5823542. PMID 29419376.
- ^ Page Module:Citation/CS1/styles.css has no content.Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME (2015). "Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression". PLOS ONE. 10 (2) e0117758. Bibcode:2015PLoSO..1017758P. doi:10.1371/journal.pone.0117758. PMC 4333349. PMID 25693195. Open access icon
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