HECT domain
Page Module:Infobox/styles.css has no content.
| HECT-domain (ubiquitin-transferase) | |||||||
|---|---|---|---|---|---|---|---|
| Lua error in package.lua at line 80: module 'Module:InfoboxImage/data' not found. structure of an e6ap-ubch7 complex: insights into the ubiquitination pathway | |||||||
| Identifiers | |||||||
| Symbol | HECT | ||||||
| Pfam | PF00632 | ||||||
| InterPro | IPR000569 | ||||||
| SCOP2 | 1d5f / SCOPe / SUPFAM | ||||||
Page Module:Infobox/styles.css has no content.
| |||||||
In molecular biology, the HECT domain is a protein domain found in ubiquitin-protein ligases. The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus'.[1] Proteins containing this domain at the C terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thioester formation. Human thyroid receptor interacting protein 12 (TRIP12), which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human E6AP ubiquitin-protein ligase interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the p53 tumour-suppressor protein for ubiquitin-mediated proteolysis.
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Huibregtse JM, Scheffner M, Beaudenon S, Howley PM (March 1995). "A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2563–7. Bibcode:1995PNAS...92.2563H. doi:10.1073/pnas.92.7.2563. PMC 42258. PMID 7708685.
Script error: No such module "InterPro content".
