Haloprogin

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Haloprogin
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Clinical data
Routes of
administration		Topical
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Legal status
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Identifiers
  • 1,2,4-Trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
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Chemical and physical data
FormulaC9H4Cl3IO
Molar mass361.38 g·mol−1
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Melting point113.5 °C (236.3 °F)
Solubility in waterInsoluble mg/mL (20 °C)
  • Clc1cc(OCC#CI)c(Cl)cc1Cl
  • InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2 checkY
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Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections.[1] It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik.

Action

Haloprogin was previously used in 1% topical creams as an antifungal agent. It was marketed over-the-counter primarily to treat tinea infections of the skin. The mechanism of action is unknown.[2]

Haloprogin had a high incidence of side effects including: irritation, burning, vesiculation (blisters), scaling, and itching. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.[3]

References

  1. ^ Page Module:Citation/CS1/styles.css has no content.Rudolph RI (December 1979). "Haloprogin as treatment for fungal infections". Clinical and Experimental Dermatology. 4 (4): 548. doi:10.1111/j.1365-2230.1979.tb01656.x. PMID 161212. S2CID 71471801.
  2. ^ Page Module:Citation/CS1/styles.css has no content."Haloprogin". Drugs@FDA. Food and Drug Administration. Archived from the original on September 26, 2006. Retrieved 2007-02-17.
  3. ^ Page Module:Citation/CS1/styles.css has no content."Haloprogin". DrugBank. University of Alberta. Nov 6, 2006. Retrieved 2007-02-17.

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