IFIT2
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene.[1][2][3] Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein.[4] The IFIT2 gene is one of the many genes that are stimulated by type 1 interferons to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one of the many type 1 interferon-stimulated genes.[4][5][6]
Clinical significance
IFIT2 may play a role in preventing tumor progression.[7] Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[8]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763. S2CID 42406993.
- ^ Page Module:Citation/CS1/styles.css has no content.Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. Bibcode:1988FEBSL.231..164W. doi:10.1016/0014-5793(88)80724-5. PMID 3360121. S2CID 22937671.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2".
- ^ a b Page Module:Citation/CS1/styles.css has no content.Mears HV, Sweeney TR (November 2018). "Better together: the role of IFIT protein-protein interactions in the antiviral response". The Journal of General Virology. 99 (11): 1463–1477. doi:10.1099/jgv.0.001149. PMID 30234477.
- ^ Page Module:Citation/CS1/styles.css has no content.Zhou X, Michal JJ, Zhang L, Ding B, Lunney JK, Liu B, Jiang Z (2013). "Interferon induced IFIT family genes in host antiviral defense". International Journal of Biological Sciences. 9 (2): 200–8. doi:10.7150/ijbs.5613. PMC 3584916. PMID 23459883.
- ^ Page Module:Citation/CS1/styles.css has no content.Lang R, Li H, Luo X, Liu C, Zhang Y, Guo S, Xu J, Bao C, Dong W, Yu Y (2022). "Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases". Frontiers in Immunology. 13 1008072. doi:10.3389/fimmu.2022.1008072. PMC 9618809. PMID 36325336.
- ^ Page Module:Citation/CS1/styles.css has no content.Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC (2008). "IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma". Mol. Cancer Res. 6 (9): 1431–9. doi:10.1158/1541-7786.MCR-08-0141. PMID 18819931.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167.
- Page Module:Citation/CS1/styles.css has no content.Wathelet MG, Clauss IM, Content J, Huez GA (1988). "Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses". Eur. J. Biochem. 174 (2): 323–9. doi:10.1111/j.1432-1033.1988.tb14101.x. PMID 2454816.
- Page Module:Citation/CS1/styles.css has no content.Ulker N, Zhang X, Samuel CE (1988). "Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component". J. Biol. Chem. 262 (35): 16798–803. doi:10.1016/S0021-9258(18)45454-3. PMID 3119591.
- Page Module:Citation/CS1/styles.css has no content.Levy D, Larner A, Chaudhuri A, Babiss LE, Darnell JE (1987). "Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8929–33. doi:10.1073/pnas.83.23.8929. PMC 387047. PMID 3466167.
- Page Module:Citation/CS1/styles.css has no content.Zhu H, Cong JP, Shenk T (1998). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13985–90. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.
- Page Module:Citation/CS1/styles.css has no content.Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, Filiukova OB, Konovalova SN, Kachko AA, Protopopova EV, Nikolaev LG, Loktev VB, Sverdlov ED (2003). "[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]". Bioorg. Khim. 29 (2): 175–80. doi:10.1023/a:1023260415910. PMID 12708317. S2CID 34300356.
- Page Module:Citation/CS1/styles.css has no content.Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Page Module:Citation/CS1/styles.css has no content.Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Page Module:Citation/CS1/styles.css has no content.Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. doi:10.1074/jbc.M605771200. PMID 16973618.
- Page Module:Citation/CS1/styles.css has no content.Saha S, Sugumar P, Bhandari P, Rangarajan PN (2006). "Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein". J. Gen. Virol. 87 (Pt 11): 3285–9. doi:10.1099/vir.0.82107-0. PMID 17030862.
- Page Module:Citation/CS1/styles.css has no content.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
