IGSF8
Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.[1][2][3] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.[4] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).[4] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,[4] and has been proposed as a potential therapeutic target in gliomas.[5] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.[4]
Cancer biomarker
In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.[5] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.[6]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–40554. doi:10.1074/jbc.M107338200. PMID 11504738.
- ^ Page Module:Citation/CS1/styles.css has no content.Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–5121. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".
- ^ a b c d Page Module:Citation/CS1/styles.css has no content.Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, et al. (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Ren J, Huang P, Wang F (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118. PMID 38453613.
- ^ Page Module:Citation/CS1/styles.css has no content.Trinidad CV, Pathak HB, Cheng S, Tzeng S, Madan R, Sardiu ME, et al. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1) 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107. PMID 37884576.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells". Biochem. J. 373 (Pt 2): 409–421. doi:10.1042/BJ20030343. PMC 1223506. PMID 12708969.
- Page Module:Citation/CS1/styles.css has no content.Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells". Cancer Res. 63 (10): 2665–2674. PMID 12750295.
- Page Module:Citation/CS1/styles.css has no content.Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–664. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
- Page Module:Citation/CS1/styles.css has no content.Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5". J. Cell Biol. 163 (5): 1167–1177. doi:10.1083/jcb.200309113. PMC 2173626. PMID 14662754.
- Page Module:Citation/CS1/styles.css has no content.Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Page Module:Citation/CS1/styles.css has no content.Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions". Blood. 103 (8): 3013–3019. doi:10.1182/blood-2003-07-2201. PMID 15070678.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. Chem. 281 (18): 12976–12985. doi:10.1074/jbc.M510617200. PMID 16537545.
- Page Module:Citation/CS1/styles.css has no content.Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins". J. Biol. Chem. 281 (28): 19665–19675. doi:10.1074/jbc.M602116200. PMID 16690612.
- Page Module:Citation/CS1/styles.css has no content.Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells". Mol. Cell. Biol. 27 (21): 7718–7726. doi:10.1128/MCB.00180-07. PMC 2169036. PMID 17785435.
External links
- IGSF8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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