ITPKB
Template:Cs1 config Template:Short description An Error has occurred retrieving Wikidata item for infobox Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.[1][2]
Function
The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. ITPKB protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate, which releases calcium from intracellular store in the endoplasmic reticulum by gating the inositol trisphosphate receptor. ITPKB produces Ins(1,3,4,5)P4, which does not gate the inositol trisphosphate receptor. The enzyme specifically phosphorylates the 1,4,5 isomer of IP3. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.[3] Itpkb regulates immune cell function and is required for T and B cell development.[4]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Takazawa K, Perret J, Dumont JE, Erneux C (Oct 1991). "Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme". Biochem J. 278 (3): 883–6. doi:10.1042/bj2780883. PMC 1151429. PMID 1654894.
- ^ Page Module:Citation/CS1/styles.css has no content.Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG (Dec 1992). "Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization". Genomics. 14 (2): 546–7. doi:10.1016/S0888-7543(05)80265-4. PMID 1330886.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: ITPKB inositol 1,4,5-trisphosphate 3-kinase B".
- ^ Page Module:Citation/CS1/styles.css has no content.Sauer K, Cooke MP (April 2010). "Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate". Nat. Rev. Immunol. 10 (4): 257–71. doi:10.1038/nri2745. PMC 2922113. PMID 20336153.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Szlufcik K, Missiaen L, Parys JB, et al. (2006). "Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences". Biol. Cell. 98 (1): 1–14. doi:10.1042/BC20050031. PMID 16354157. S2CID 36990427.
Lua error in package.lua at line 80: module 'Module:Navbox/configuration' not found.
