Iproclozide

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Iproclozide
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Clinical data
Routes of
administration		Oral
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Legal status
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Identifiers
  • 2-(4-chlorophenoxy)-N-isopropyl-acetohydrazide
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Chemical and physical data
FormulaC11H15ClN2O2
Molar mass242.70 g·mol−1
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  • Clc1ccc(OCC(=O)NNC(C)C)cc1
  • InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15) checkY
  • Key:GGECDTUJZOXAAR-UHFFFAOYSA-N checkY
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Iproclozide (trade names Sursum, Sinderesin) is an irreversible and selective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant, but has since been discontinued.[2] It has been known to cause fulminant hepatitis and there have been at least three reported fatalities due to administration of the drug.[3][4]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in português do Brasil). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Suerinck A, Suerinck E (April 1966). "[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]". Journal de Médecine de Lyon. 47 (96): 573–586. PMID 5930723.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP (September 1978). "Iproclozide fulminant hepatitis. Possible role of enzyme induction". Gastroenterology. 75 (3): 492–496. doi:10.1016/0016-5085(78)90856-9. PMID 680506.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Kaplowitz N, DeLeve LD (2003). Drug-induced liver disease. Informa Health Care. p. 455. ISBN 0-8247-0811-3.

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