KRT86
Template:Short description An Error has occurred retrieving Wikidata item for infobox The KRT86 gene encodes for keratin, type II cuticular Hb6 protein in humans.[1][2][3]
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRT81, KRT83, and KRT86, is highly related. The other, less-related subfamily includes KRT82, KRT84, and KRT85. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRT81 and KRT83, is found primarily in the hair cortex. Mutations in this gene and KRT81 have been observed in patients with a rare dominant hair disease, monilethrix.[3]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Winter H, Rogers MA, Langbein L, Stevens HP, Leigh IM, Labreze C, Roul S, Taieb A, Krieg T, Schweizer J (Aug 1997). "Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix". Nat Genet. 16 (4): 372–4. doi:10.1038/ng0897-372. PMID 9241275. S2CID 25352502.
- ^ Page Module:Citation/CS1/styles.css has no content.Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: KRT86 keratin 86".
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Langbein L, Schweizer J (2005). "Keratins of the human hair follicle". Int. Rev. Cytol. International Review of Cytology. 243: 1–78. doi:10.1016/S0074-7696(05)43001-6. ISBN 9780123646477. PMID 15797458.
- Page Module:Citation/CS1/styles.css has no content.Rogers MA, Nischt R, Korge B, et al. (1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp. Cell Res. 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444.
- Page Module:Citation/CS1/styles.css has no content.Rogers MA, Langbein L, Praetzel S, et al. (1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation. 61 (3): 187–94. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137.
- Page Module:Citation/CS1/styles.css has no content.Winter H, Rogers MA, Gebhardt M, et al. (1998). "A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix". Hum. Genet. 101 (2): 165–9. doi:10.1007/s004390050607. PMID 9402962. S2CID 20555394.
- Page Module:Citation/CS1/styles.css has no content.Bowden PE, Hainey SD, Parker G, et al. (1998). "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle". J. Invest. Dermatol. 110 (2): 158–64. doi:10.1046/j.1523-1747.1998.00097.x. PMID 9457912.
- Page Module:Citation/CS1/styles.css has no content.Winter H, Clark RD, Tarras-Wahlberg C, et al. (1999). "Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6". J. Invest. Dermatol. 113 (2): 263–6. doi:10.1046/j.1523-1747.1999.00685.x. PMID 10469314.
- Page Module:Citation/CS1/styles.css has no content.Korge BP, Hamm H, Jury CS, et al. (1999). "Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype". J. Invest. Dermatol. 113 (4): 607–12. doi:10.1046/j.1523-1747.1999.00722.x. PMID 10504448.
- Page Module:Citation/CS1/styles.css has no content.Pearce EG, Smith SK, Lanigan SW, Bowden PE (2000). "Two different mutations in the same codon of a type II hair keratin (hHb6) in patients with monilethrix". J. Invest. Dermatol. 113 (6): 1123–7. doi:10.1046/j.1523-1747.1999.00777.x. PMID 10594761.
- Page Module:Citation/CS1/styles.css has no content.Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol. 114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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