LTBP2
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.[1][2]
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins.
It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.[2]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH (Jan 1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J Biol Chem. 269 (51): 32469–78. doi:10.1016/S0021-9258(18)31659-4. PMID 7798248.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2".
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Chambaz EM, Souchelnitskiy S, Pellerin S, et al. (1996). "Transforming growth factors-beta s: a multifunctional cytokine family. Implication in the regulation of adrenocortical cell endocrine functions". Horm. Res. 45 (3–5): 222–6. doi:10.1159/000184792. PMID 8964588.
- Page Module:Citation/CS1/styles.css has no content.Munger JS, Harpel JG, Gleizes PE, et al. (1997). "Latent transforming growth factor-beta: structural features and mechanisms of activation". Kidney Int. 51 (5): 1376–82. doi:10.1038/ki.1997.188. PMID 9150447.
- Page Module:Citation/CS1/styles.css has no content.Taipale J, Saharinen J, Keski-Oja J (1998). "Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion". Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion. Advances in Cancer Research. Vol. 75. pp. 87–134. doi:10.1016/S0065-230X(08)60740-X. ISBN 978-0-12-006675-9. PMID 9709808.
{{cite book}}:|journal=ignored (help) - Page Module:Citation/CS1/styles.css has no content.Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
- Page Module:Citation/CS1/styles.css has no content.Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem. J. 352 Pt 3 (3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
- Page Module:Citation/CS1/styles.css has no content.Li X, Yin W, Pérez-Jurado L, et al. (1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)" (PDF). Mamm. Genome. 6 (1): 42–5. doi:10.1007/BF00350892. hdl:2027.42/47013. PMID 7719025. S2CID 32672633.
- Page Module:Citation/CS1/styles.css has no content.Bashir MM, Han MD, Abrams WR, et al. (1996). "Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2". Int. J. Biochem. Cell Biol. 28 (5): 531–42. doi:10.1016/1357-2725(95)00167-0. PMID 8697098.
- Page Module:Citation/CS1/styles.css has no content.Hyytiäinen M, Taipale J, Heldin CH, Keski-Oja J (1998). "Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release". J. Biol. Chem. 273 (32): 20669–76. doi:10.1074/jbc.273.32.20669. PMID 9685426.
- Page Module:Citation/CS1/styles.css has no content.Saharinen J, Keski-Oja J (2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463.
- Page Module:Citation/CS1/styles.css has no content.Wu X, Blanck A, Norstedt G, et al. (2002). "Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium". Mol. Hum. Reprod. 8 (3): 246–54. doi:10.1093/molehr/8.3.246. PMID 11870232.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
- Page Module:Citation/CS1/styles.css has no content.Vehviläinen P, Hyytiäinen M, Keski-Oja J (2003). "Latent transforming growth factor-beta-binding protein 2 is an adhesion protein for melanoma cells". J. Biol. Chem. 278 (27): 24705–13. doi:10.1074/jbc.M212953200. PMID 12716902.
- Page Module:Citation/CS1/styles.css has no content.Hirani R, Hanssen E, Gibson MA (2007). "LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein". Matrix Biol. 26 (4): 213–23. CiteSeerX 10.1.1.328.5118. doi:10.1016/j.matbio.2006.12.006. PMID 17293099.
