MAGED1
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Template:Cs1 config Template:Short description An Error has occurred retrieving Wikidata item for infobox Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene.[1][2]
Function
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.[2]
MAGED was found to be deleted in a group of children with an intellectual disability disorder caused by a Xp11.22 deletion.[3]
Maged1 plays a role in controlling the reward circuitry in the brain of mice that is responsible for addictive behaviors.[4] More recently, it has been shown to play a role in drug addiction through an epigenetic mechanism involving the monoubiquitination of H2A, which represses gene expression via interaction with the deubiquitinase USP7.[5]
Interactions
MAGED1 has been shown to interact with UNC5A,[6] PJA1,[7] XIAP,[8] and USP7.[5]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Põld M, Zhou J, Chen GL, Hall JM, Vescio RA, Berenson JR (Sep 1999). "Identification of a new, unorthodox member of the MAGE gene family". Genomics. 59 (2): 161–7. doi:10.1006/geno.1999.5870. PMID 10409427.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: MAGED1 melanoma antigen family D, 1".
- ^ Page Module:Citation/CS1/styles.css has no content.Grau C, Starkovich M, Azamian MS, Xia F, Cheung SW, Evans P, et al. (2017). "Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability". PLOS ONE. 12 (4) e0175962. Bibcode:2017PLoSO..1275962G. doi:10.1371/journal.pone.0175962. PMC 5393878. PMID 28414775.
- ^ Page Module:Citation/CS1/styles.css has no content.De Backer JF, Monlezun S, Detraux B, Gazan A, Vanopdenbosch L, Cheron J, et al. (July 2018). "Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine". EMBO Reports. 19 (9) e45089. doi:10.15252/embr.201745089. PMC 6123657. PMID 30002119.*Template:Lay source
- ^ a b Page Module:Citation/CS1/styles.css has no content.Cheron J, Beccari L, Hagué P, Icick R, Despontin C, Carusone T, et al. (December 2023). "USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder". Nature Communications. 14 (1) 8481. Bibcode:2023NatCo..14.8481C. doi:10.1038/s41467-023-44120-2. PMC 10733359. PMID 38123574.
- ^ Page Module:Citation/CS1/styles.css has no content.Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
- ^ Page Module:Citation/CS1/styles.css has no content.Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (Jun 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
- ^ Page Module:Citation/CS1/styles.css has no content.Jordan BW, Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, et al. (Oct 2001). "Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death". J. Biol. Chem. 276 (43): 39985–9. doi:10.1074/jbc.C100171200. PMID 11546791.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, et al. (2000). "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis". Neuron. 27 (2): 279–88. doi:10.1016/S0896-6273(00)00036-2. PMID 10985348.
- Page Module:Citation/CS1/styles.css has no content.Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K (2001). "Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function". J. Biol. Chem. 276 (7): 5331–8. doi:10.1074/jbc.M008590200. PMID 11084035.
- Page Module:Citation/CS1/styles.css has no content.Kubu CJ, Goldhawk DG, Barker PA, Verdi JM (2001). "Identification of the translational initiation codon in human MAGED1". Genomics. 70 (1): 150–2. doi:10.1006/geno.2000.6356. PMID 11087672.
- Page Module:Citation/CS1/styles.css has no content.Zhang CG, Xing GC, Wei HD, Yu YT, He FC (2001). "[A new melanoma antigen-encoding gene subfamily in human chromosome X]". Yi Chuan Xue Bao. 28 (3): 197–203. PMID 11280991.
- Page Module:Citation/CS1/styles.css has no content.Stone B, Schummer M, Paley PJ, Crawford M, Ford M, Urban N, et al. (2001). "MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily". Gene. 267 (2): 173–82. doi:10.1016/S0378-1119(01)00406-1. PMID 11313144.
- Page Module:Citation/CS1/styles.css has no content.Jordan BW, Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, et al. (2001). "Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death". J. Biol. Chem. 276 (43): 39985–9. doi:10.1074/jbc.C100171200. PMID 11546791.
- Page Module:Citation/CS1/styles.css has no content.Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
- Page Module:Citation/CS1/styles.css has no content.Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
- Page Module:Citation/CS1/styles.css has no content.Kendall SE, Goldhawk DE, Kubu C, Barker PA, Verdi JM (2003). "Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis". Mech. Dev. 117 (1–2): 187–200. doi:10.1016/S0925-4773(02)00204-6. PMID 12204258. S2CID 8919247.
- Page Module:Citation/CS1/styles.css has no content.Williams ME, Strickland P, Watanabe K, Hinck L (2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
- Page Module:Citation/CS1/styles.css has no content.Matsuda T, Suzuki H, Oishi I, Kani S, Kuroda Y, Komori T, et al. (2003). "The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution". J. Biol. Chem. 278 (31): 29057–64. doi:10.1074/jbc.M302199200. PMID 12754255.
- Page Module:Citation/CS1/styles.css has no content.Wen CJ, Xue B, Qin WX, Yu M, Zhang MY, Zhao DH, et al. (2004). "hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation". FEBS Lett. 564 (1–2): 171–6. Bibcode:2004FEBSL.564..171W. doi:10.1016/S0014-5793(04)00353-9. PMID 15094062. S2CID 39965080.
- Page Module:Citation/CS1/styles.css has no content.Bertrand M, Huijbers I, Chomez P, De Backer O (2005). "Comparative expression analysis of the MAGED genes during embryogenesis and brain development". Dev. Dyn. 230 (2): 325–34. doi:10.1002/dvdy.20026. PMID 15162511.
- Page Module:Citation/CS1/styles.css has no content.Tian XX, Rai D, Li J, Zou C, Bai Y, Wazer D, et al. (2005). "BRCA2 suppresses cell proliferation via stabilizing MAGE-D1". Cancer Res. 65 (11): 4747–53. doi:10.1158/0008-5472.CAN-05-0018. PMC 3295243. PMID 15930293.
- Page Module:Citation/CS1/styles.css has no content.Xue B, Wen C, Shi Y, Zhao D, Li C (2005). "Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion". Biochem. Biophys. Res. Commun. 336 (1): 247–51. Bibcode:2005BBRC..336..247X. doi:10.1016/j.bbrc.2005.08.069. PMID 16125672.
- Page Module:Citation/CS1/styles.css has no content.Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
