MAPK10
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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.[1][2][3]
Function
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
MAPK10 has been shown to interact with MAPK8IP3.[4][5][6]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, et al. (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". The EMBO Journal. 15 (11): 2760–2770. doi:10.1002/j.1460-2075.1996.tb00636.x. PMC 450211. PMID 8654373.
- ^ Page Module:Citation/CS1/styles.css has no content.Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002). "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". Journal of Human Genetics. 47 (11): 614–619. doi:10.1007/s100380200094. PMID 12436199.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: MAPK10 mitogen-activated protein kinase 10".
- ^ Page Module:Citation/CS1/styles.css has no content.Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, et al. (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Molecular and Cellular Biology. 19 (11): 7539–7548. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
- ^ Page Module:Citation/CS1/styles.css has no content.Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Molecular and Cellular Biology. 20 (3): 1030–1043. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
- ^ Page Module:Citation/CS1/styles.css has no content.Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, et al. (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". Journal of Biological Chemistry. 277 (43): 40703–40709. doi:10.1074/jbc.M202004200. hdl:2297/2692. PMID 12189133.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Freedman BD, Liu QH, Del Corno M, Collman RG (2003). "HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages". Immunologic Research. 27 (2–3): 261–276. doi:10.1385/IR:27:2-3:261. PMID 12857973. S2CID 32006625.
- Page Module:Citation/CS1/styles.css has no content.Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–682. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
- Page Module:Citation/CS1/styles.css has no content.Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR (1991). "Phosphorylation of c-jun mediated by MAP kinases". Nature. 353 (6345): 670–674. Bibcode:1991Natur.353..670P. doi:10.1038/353670a0. PMID 1922387. S2CID 29557176.
- Page Module:Citation/CS1/styles.css has no content.Mohit AA, Martin JH, Miller CA (1995). "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system". Neuron. 14 (1): 67–78. doi:10.1016/0896-6273(95)90241-4. PMID 7826642. S2CID 14107133.
- Page Module:Citation/CS1/styles.css has no content.Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Page Module:Citation/CS1/styles.css has no content.Jabado N, Pallier A, Jauliac S, Fischer A, Hivroz C (1997). "gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes". European Journal of Immunology. 27 (2): 397–404. doi:10.1002/eji.1830270209. PMID 9045910. S2CID 23787450.
- Page Module:Citation/CS1/styles.css has no content.Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, et al. (1997). "Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene". Nature. 389 (6653): 865–870. Bibcode:1997Natur.389..865Y. doi:10.1038/39899. PMID 9349820. S2CID 4430535.
- Page Module:Citation/CS1/styles.css has no content.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Page Module:Citation/CS1/styles.css has no content.Hu MC, Qiu WR, Wang YP (1997). "JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases". Oncogene. 15 (19): 2277–2287. doi:10.1038/sj.onc.1201401. PMID 9393873.
- Page Module:Citation/CS1/styles.css has no content.Lannuzel A, Barnier JV, Hery C, Huynh VT, Guibert B, Gray F, et al. (1997). "Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons". Annals of Neurology. 42 (6): 847–856. doi:10.1002/ana.410420605. PMID 9403476. S2CID 36951375.
- Page Module:Citation/CS1/styles.css has no content.Xie X, Gu Y, Fox T, Coll JT, Fleming MA, Markland W, et al. (1998). "Crystal structure of JNK3: a kinase implicated in neuronal apoptosis". Structure. 6 (8). London, England: 983–991. doi:10.1016/S0969-2126(98)00100-2. PMID 9739089.
- Page Module:Citation/CS1/styles.css has no content.The Sanger Centre, The Washington University Genome Sequencing Cente (1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Page Module:Citation/CS1/styles.css has no content.Koyano S, Ito M, Takamatsu N, Shiba T, Yamamoto K, Yoshioka K (1999). "A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1". FEBS Letters. 457 (3): 385–388. Bibcode:1999FEBSL.457..385K. doi:10.1016/S0014-5793(99)01084-4. PMID 10471813. S2CID 32690852.
- Page Module:Citation/CS1/styles.css has no content.Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, et al. (1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Molecular and Cellular Biology. 19 (11): 7539–7548. doi:10.1128/mcb.19.11.7539. PMC 84763. PMID 10523642.
- Page Module:Citation/CS1/styles.css has no content.Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Molecular and Cellular Biology. 20 (3): 1030–1043. doi:10.1128/MCB.20.3.1030-1043.2000. PMC 85220. PMID 10629060.
- Page Module:Citation/CS1/styles.css has no content.Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, et al. (2000). "Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1". Biochemistry. 39 (11): 3141–3148. doi:10.1021/bi992410. PMID 10715136.
- Page Module:Citation/CS1/styles.css has no content.McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, et al. (2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science. 290 (5496). New York, N.Y.: 1574–1577. Bibcode:2000Sci...290.1574M. doi:10.1126/science.290.5496.1574. PMID 11090355.
- Page Module:Citation/CS1/styles.css has no content.Pouysségur J (2000). "Signal transduction. An arresting start for MAPK". Science. 290 (5496). New York, N.Y.: 1515–1518. doi:10.1126/science.290.5496.1515. PMID 11185509. S2CID 84778351.
- Page Module:Citation/CS1/styles.css has no content.Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, et al. (2001). "ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation". Nature Cell Biology. 3 (3): 325–330. doi:10.1038/35060131. PMID 11231586. S2CID 34298842.
External links
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