Masoprocol

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Masoprocol
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Clinical data
Trade namesActinex
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Topical
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Pharmacokinetic data
BioavailabilityVery low
Identifiers
  • 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
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Chemical and physical data
FormulaC18H22O4
Molar mass302.370 g·mol−1
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  • Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
  • InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ checkY
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Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. It is the meso form of nordihydroguaiaretic acid that is taken by mouth. The substance is being studied in the treatment of prostate cancer.

Masoprocol is also called NDGA, and Actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi:10.1152/ajpendo.2000.279.3.E593. PMID 10950827.

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