Matrine

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Matrine
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Clinical data
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  • none
Legal status
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  • Unscheduled, sold OTC in US
Identifiers
  • (1R,2R,9S,17S)-7,13-Diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
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Chemical and physical data
FormulaC15H24N2O
Molar mass248.370 g·mol−1
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  • C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1
  • InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 ☒N
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Matrine is an alkaloid found in plants from the family Fabaceae. It has a variety of pharmacological effects, including in-vitro anti-cancer effects,[1] as well as κ-opioid and μ-opioid receptor agonism.[2][3]

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.[4] Matrine can be commercially extracted from the traditional Chinese medical herb Sophora flavescens Ait.

Mu opioid agonism is associated with euphoria, while kappa opioid agonism is associated with dysphoria and psychotomimetic hallucinations (as seen in the kappa-agonist Salvinorin A). Both receptors are known to produce analgesia when activated.

Matrine and the related compound oxymatrine have a toxic effect against the formosan subterranean termite.[5] Additionally, it acts as a nematicide against the pine wood nematode which causes pine wilt,[6] as well as pathogenic nematodes which target humans.[7]

Matrine alleviates neuro-inflammation and oxidative stress in the brain caused by acute liver injury, thus producing antianxiety and antidepression effects.[8]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, et al. (April 2009). "Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration". Cytotechnology. 59 (3): 191–200. doi:10.1007/s10616-009-9211-2. PMC 2774570. PMID 19649719.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Xiao P, Kubo H, Ohsawa M, Higashiyama K, Nagase H, Yan YN, et al. (April 1999). "kappa-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice". Planta Medica. 65 (3): 230–233. Bibcode:1999PlMed..65..230X. doi:10.1055/s-1999-14080. PMID 10232067. S2CID 260280876.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Higashiyama K, Takeuchi Y, Yamauchi T, Imai S, Kamei J, Yajima Y, et al. (May 2005). "Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects". Biological & Pharmaceutical Bulletin. 28 (5): 845–848. doi:10.1248/bpb.28.845. PMID 15863891.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J (February 2008). "Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells". Planta Medica. 74 (3): 245–251. Bibcode:2008PlMed..74..245M. doi:10.1055/s-2008-1034304. PMID 18283616. S2CID 260282269.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Mao L, Henderson G (June 2007). "Antifeedant activity and acute and residual toxicity of alkaloids from Sophora flavescens (leguminosae) against formosan subterranean termites (Isoptera: Rhinotermitidae)". Journal of Economic Entomology. 100 (3): 866–870. doi:10.1093/jee/100.3.866. PMID 17598549.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Matsuda K, Yamada K, Kimura M, Hamada M (1991). "Nematicidal activity of matrine and its derivatives against pine wood nematodes". Journal of Agricultural and Food Chemistry. 39 (1): 189–191. Bibcode:1991JAFC...39..189M. doi:10.1021/jf00001a038.
  7. ^ Page Module:Citation/CS1/styles.css has no content.Terada M, Sano M, Ishii AI, Kino H, Fukushima S, Noro T (February 1982). "[Studies on chemotherapy of parasitic helminths (IV). Effects of alkaloids from Sophora flavescens on the motility of parasitic helminths and isolated host tissues (author's transl)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 79 (2): 105–111. doi:10.1254/fpj.79.105. PMID 7200047.
  8. ^ Page Module:Citation/CS1/styles.css has no content.Khan A, Shal B, Naveed M, Shah FA, Atiq A, Khan NU, et al. (May 2019). "Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury". Neurotoxicology. 72: 38–50. Bibcode:2019NeuTx..72...38K. doi:10.1016/j.neuro.2019.02.002. PMID 30738807. S2CID 73445828.

See also

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