Melevodopa

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Melevodopa
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Clinical data
Trade namesLevomet
Other namesLevodopa methyl ester; L-DOPA methyl ester; LDME; CHF-1301
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Identifiers
  • methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
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Chemical and physical data
FormulaC10H13NO4
Molar mass211.217 g·mol−1
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Melevodopa, also known as levodopa methyl ester (LDME) and sold under the brand name Levomet, is a dopaminergic agent. It is the methyl ester of levodopa.[1] It is used in oral tablet form as an effervescent prodrug with 250 times the water solubility of tablet levodopa.[2][3] In combination with carbidopa, as melevodopa/carbidopa (brand name Sirio), it is approved for use in the treatment of Parkinson's disease.[4][5]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Buckingham J, Baggaley K, Roberts A, Szabo L (2010). Dictionary of Alkaloids with CD-ROM. CRC Press. p. 103. ISBN 978-1-4200-7770-4. Retrieved 28 September 2024.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Hickey P, Stacy M (2011). "Available and emerging treatments for Parkinson's disease: a review". Drug Design, Development and Therapy. 5: 241–254. doi:10.2147/DDDT.S11836. PMC 3096539. PMID 21607020.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Stocchi F, Marconi S (July 2010). "Factors associated with motor fluctuations and dyskinesia in Parkinson Disease: potential role of a new melevodopa plus carbidopa formulation (Sirio)". Clin Neuropharmacol. 33 (4): 198–203. doi:10.1097/WNF.0b013e3181de8924. PMID 20414107.
  4. ^ Page Module:Citation/CS1/styles.css has no content."Melevodopa/carbidopa". AdisInsight. Springer Nature Switzerland AG. 23 September 2021. Retrieved 27 September 2024.
  5. ^ Page Module:Citation/CS1/styles.css has no content."Melevodopa: Uses, Interactions, Mechanism of Action". DrugBank Online. 1 April 2015. Retrieved 27 September 2024.


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