Mequinol

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Mequinol
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Clinical data
Other names4-Hydroxyanisole; para-Guaiacol
AHFS/Drugs.comInternational Drug Names
MedlinePlusa682437
Routes of
administration		Topical
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Legal status
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Identifiers
  • 4-Methoxyphenol
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Chemical and physical data
FormulaC7H8O2
Molar mass124.139 g·mol−1
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Density1.55 g/cm3
Melting point52.5 °C (126.5 °F)
Boiling point243 °C (469 °F)
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Mequinol, MeHQ or 4-methoxyphenol, is an organic compound with the formula Page Module:Chem2/styles.css has no content.CH3OC6H4OH. It is a phenol with a methoxy group in the para position. A colorless solid, it is used in dermatology[1] and organic chemistry.[2]

Use in dermatology

Mequinol is a common active ingredient in topical drugs used for skin depigmentation. As a topical drug mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% mequinol and 0.01% tretinoin by mass.[1] Dermatologists commonly prescribe the drug to treat liver spots.

Lower dosages of mequinol have been used in conjunction with a Q-switched laser to depigment skin in patients with disseminated idiopathic vitiligo.[3]

Organic chemistry

In organic chemistry 4-methoxyphenol is used as a polymerisation inhibitor (e.g. acrylates or styrene monomers).[2]

4-Methoxyphenol can be produced from p-benzoquinone and methanol via a free radical reaction.[4][5]

Safety

The U.S. National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure limit (REL) of 5 mg/m3 over an 8-hour workday.[6]

See also

References

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  1. ^ a b Page Module:Citation/CS1/styles.css has no content.Stiefel Laboratories, Inc. "Full Prescribing Information" (PDF). US Food and Drug Administration. Archived from the original (PDF) on January 2, 2015. Retrieved 2 January 2015.
  2. ^ a b Script error: No such module "Template wrapper".
  3. ^ Page Module:Citation/CS1/styles.css has no content.Komen L, Zwertbroek L, Burger SJ, van der Veen JP, de Rie MA, Wolkerstorfer A (December 2013). "Q-switched laser depigmentation in vitiligo, most effective in active disease". The British Journal of Dermatology. 169 (6): 1246–51. doi:10.1111/bjd.12571. PMID 23909405. S2CID 43542975.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Gambarotti C, Melone L, Punta C, Shisodia SU (2013). "Selective Monoetherification of 1,4-Hydroquinone Promoted by NaNO2". Current Organic Chemistry. 17 (10): 1108–1113. doi:10.2174/1385272811317100011.
  5. ^ Page Template:Citation/styles.css has no content.US 4933504, Correale M, Panseri P, Romano U, Minisci F, "Process for the preparation of mono-ethers of hydroquinones" 
  6. ^ Page Module:Citation/CS1/styles.css has no content."4-Methoxyphenol". NIOSH Pocket Guide to Chemical Hazards. CDC. Retrieved 2015-11-20.

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