Metixene

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Metixene
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Clinical data
AHFS/Drugs.comInternational Drug Names
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Legal status
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Identifiers
  • 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
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Chemical and physical data
FormulaC20H23NS
Molar mass309.47 g·mol−1
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  • CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
  • InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3
  • Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N
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Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent.[2] It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases.[3]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in português do Brasil). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Morton IK, Hall JM (1999). "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178. ISBN 978-94-011-4439-1.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. 133 (24) e161142. doi:10.1172/JCI161142. PMC 10721147. PMID 37847564.


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