NPAS1

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neuronal PAS domain protein 1
Identifiers
SymbolNPAS1
NCBI gene4861
HGNC7894
OMIM603346
RefSeqNM_002517
UniProtQ99742
Other data
LocusChr. 19 q13.2-13.3
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Search for
StructuresSwiss-model
DomainsInterPro

NPAS1 is a basic helix-loop-helix transcription factor.[1][2] Npas1 is expressed in the developing forebrain in neuronal precursors of GABAergic projection neurons in the globus pallidus and basal forebrain as well as cortical and hippocampal interneurons[3][4][5][6]. Experiments in mice have linked neurons expressing Npas1 in the external globus pallidus to motor control[7][8] and those in the basal forebrain to sleep-wake control[9] and stress responsiveness[10]. Knockout and gene expression experiments have linked Npas1 to the control of behaviors and genes related to neuropsychiatric disorders [11][12]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL (January 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 713–8. Bibcode:1997PNAS...94..713Z. doi:10.1073/pnas.94.2.713. PMC 19579. PMID 9012850.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (March 1997). "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J. Biol. Chem. 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Cobos, Inma; Long, Jason E.; Thwin, Myo T.; Rubenstein, John L. (2006-07-01). "Cellular Patterns of Transcription Factor Expression in Developing Cortical Interneurons". Cerebral Cortex. 16 (suppl_1): i82–i88. doi:10.1093/cercor/bhk003. ISSN 1460-2199.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Flandin, Pierre; Kimura, Shioko; Rubenstein, John L. R. (2010-02-24). "The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons". The Journal of Neuroscience. 30 (8): 2812–2823. doi:10.1523/JNEUROSCI.4228-09.2010. ISSN 0270-6474. PMC 2865856.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Nóbrega-Pereira, Sandrina; Gelman, Diego; Bartolini, Giorgia; Pla, Ramón; Pierani, Alessandra; Marín, Oscar (2010-02-24). "Origin and Molecular Specification of Globus Pallidus Neurons". The Journal of Neuroscience. 30 (8): 2824–2834. doi:10.1523/JNEUROSCI.4023-09.2010. ISSN 0270-6474. PMC 6633933.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Stanco, Amelia; Pla, Ramón; Vogt, Daniel; Chen, Yiran; Mandal, Shyamali; Walker, Jamie; Hunt, Robert; Lindtner, Susan; Erdman, Carolyn; Pieper, Andrew; Hamilton, Steven; Xu, Duan; Baraban, Scott; Rubenstein, John (3 Dec 2014). "NPAS1 Represses the Generation of Specific Subtypes of Cortical Interneurons". Neuron. 84 (5): 940–953. doi:10.1016/j.neuron.2014.10.040. PMC 4258152. PMID 25467980.
  7. ^ Page Module:Citation/CS1/styles.css has no content.Hernandez, V. M.; Hegeman, D. J.; Cui, Q.; Kelver, D. A.; Fiske, M. P.; Glajch, K. E.; Pitt, J. E.; Huang, T. Y.; Justice, N. J.; Chan, C. S. (2015-08-26). "Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus". Journal of Neuroscience. 35 (34): 11830–11847. doi:10.1523/JNEUROSCI.4672-14.2015. ISSN 0270-6474.
  8. ^ Page Module:Citation/CS1/styles.css has no content.Pamukcu, Arin; Cui, Qiaoling; Xenias, Harry S.; Berceau, Brianna L.; Augustine, Elizabeth C.; Fan, Isabel; Chalasani, Saivasudha; Hantman, Adam W.; Lerner, Talia N.; Boca, Simina M.; Chan, C. Savio (2020-10-07). "Parvalbumin + and Npas1 + Pallidal Neurons Have Distinct Circuit Topology and Function". The Journal of Neuroscience. 40 (41): 7855–7876. doi:10.1523/JNEUROSCI.0361-20.2020. ISSN 0270-6474. PMC 7548687.
  9. ^ Page Module:Citation/CS1/styles.css has no content.Troppoli, Timothy A.; Yang, Chun; Katsuki, Fumi; Uygun, David S.; Lin, Ilyan; Aguilar, David D.; Spratt, Tristan; Basheer, Radhika; McNally, James M.; Savio Chan, C.; McKenna, James T.; Brown, Ritchie E. (2024-05-21). "Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain". Proceedings of the National Academy of Sciences. 121 (21). doi:10.1073/pnas.2321410121. ISSN 0027-8424. PMC 11127008. PMID 38748575.
  10. ^ Page Module:Citation/CS1/styles.css has no content.Morais-Silva, Gessynger; Campbell, Rianne R.; Nam, Hyungwoo; Basu, Mahashweta; Pagliusi, Marco; Fox, Megan E.; Chan, C. Savio; Iñiguez, Sergio D.; Ament, Seth; Cramer, Nathan; Marin, Marcelo Tadeu; Lobo, Mary Kay (2023-01-18). "Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons". The Journal of Neuroscience. 43 (3): 405–418. doi:10.1523/JNEUROSCI.0971-22.2022. ISSN 0270-6474.
  11. ^ Page Module:Citation/CS1/styles.css has no content.Erbel-Sieler, Claudia; Dudley, Carol; Zhou, Yudong; Wu, Xinle; Estill, Sandi Jo; Han, Tina; Diaz-Arrastia, Ramon; Brunskill, Eric W.; Potter, S. Steven; McKnight, Steven L. (2004-09-14). "Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors". Proceedings of the National Academy of Sciences. 101 (37): 13648–13653. doi:10.1073/pnas.0405310101. ISSN 0027-8424. PMC 518807. PMID 15347806.
  12. ^ Page Module:Citation/CS1/styles.css has no content.Michaelson, Jacob J.; Shin, Min-Kyoo; Koh, Jin-Young; Brueggeman, Leo; Zhang, Angela; Katzman, Aaron; McDaniel, Latisha; Fang, Mimi; Pufall, Miles; Pieper, Andrew A. (2017). "Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes". Biological Psychiatry. 82 (3): 213–223. doi:10.1016/j.biopsych.2017.03.021. PMC 6901278. PMID 28499489.

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