Netilmicin

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Netilmicin
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Clinical data
Trade namesNetromycin
Other names1-N-Ethylsisomicin
AHFS/Drugs.comMonograph
MedlinePlusa605011
Routes of
administration		Topical
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Legal status
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Pharmacokinetic data
Bioavailability~0%
Elimination half-life2.5 hours
Identifiers
  • (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4-Amino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-6-(ethylamino)-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol
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Chemical and physical data
FormulaC21H41N5O7
Molar mass475.587 g·mol−1
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Netilmicin (1-N-ethylsisomicin) is a semisynthetic aminoglycoside antibiotic, and a derivative of sisomicin, produced by Micromonospora inyoensis. Aminoglycoside antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.

It was patented in 1973 and approved for medical use in 1981.[2] It was approved for medical use in the UK in December 2019, for the treatment of external infections of the eye.[3] It is on the World Health Organization's List of Essential Medicines.[4]

Comparison with drugs

According to the British National Formulary (BNF), netilmicin has similar activity to gentamicin, but less ototoxicity in those needing treatment for longer than 10 days. Netilmicin is active against a number of gentamicin-resistant Gram-negative bacteria but is less active against Pseudomonas aeruginosa than gentamicin or tobramycin.[citation needed]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content."Drug and medical device highlights 2019: Helping you maintain and improve your health". Health Canada. 18 November 2020. Retrieved 28 March 2024.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 508. ISBN 978-3-527-60749-5.
  3. ^ Page Module:Citation/CS1/styles.css has no content."Netilmicin". SPS - Specialist Pharmacy Service. 2 June 2020. Archived from the original on 24 October 2021. Retrieved 21 August 2020.
  4. ^ Page Module:Citation/CS1/styles.css has no content.World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

Further reading

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