Ninein
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Ninein is a protein that in humans is encoded by the NIN gene.[1][2][3]
Function
Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[3]
This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells.[3]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.
- ^ Page Module:Citation/CS1/styles.css has no content.Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463.
- ^ a b c Page Module:Citation/CS1/styles.css has no content."Entrez Gene: NIN ninein (GSK3B interacting protein)".
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Page Module:Citation/CS1/styles.css has no content.Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Page Module:Citation/CS1/styles.css has no content.Mack GJ, Rees J, Sandblom O, et al. (1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.
- Page Module:Citation/CS1/styles.css has no content.Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
- Page Module:Citation/CS1/styles.css has no content.Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci. 115 (Pt 9): 1825–35. doi:10.1242/jcs.115.9.1825. PMID 11956314.
- Page Module:Citation/CS1/styles.css has no content.Dammermann A, Merdes A (2002). "Assembly of centrosomal proteins and microtubule organization depends on PCM-1". J. Cell Biol. 159 (2): 255–66. doi:10.1083/jcb.200204023. PMC 2173044. PMID 12403812.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Chen CH, Howng SL, Cheng TS, et al. (2003). "Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle". Biochem. Biophys. Res. Commun. 308 (4): 975–83. doi:10.1016/S0006-291X(03)01510-9. PMID 12927815.
- Page Module:Citation/CS1/styles.css has no content.Fritzler MJ, Zhang M, Stinton LM, Rattner JB (2004). "Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia". BMC Pediatrics. 3: 11. doi:10.1186/1471-2431-3-11. PMC 222907. PMID 14503922.
- Page Module:Citation/CS1/styles.css has no content.Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Page Module:Citation/CS1/styles.css has no content.Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123. S2CID 22767022.
- Page Module:Citation/CS1/styles.css has no content.Vizmanos JL, Novo FJ, Román JP, et al. (2004). "NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder". Cancer Res. 64 (8): 2673–6. doi:10.1158/0008-5472.CAN-04-0144. PMID 15087377.
- Page Module:Citation/CS1/styles.css has no content.Howng SL, Hsu HC, Cheng TS, et al. (2004). "A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors". FEBS Lett. 566 (1–3): 162–8. doi:10.1016/j.febslet.2004.04.024. PMID 15147888.
- Page Module:Citation/CS1/styles.css has no content.Stillwell EE, Zhou J, Joshi HC (2006). "Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation". Cell Cycle. 3 (7): 923–30. doi:10.4161/cc.3.7.947. PMID 15190203.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Delgehyr N, Sillibourne J, Bornens M (2005). "Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function". J. Cell Sci. 118 (Pt 8): 1565–75. doi:10.1242/jcs.02302. PMID 15784680.
- Page Module:Citation/CS1/styles.css has no content.Cheng TS, Chang LK, Howng SL, et al. (2006). "SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization". Life Sci. 78 (10): 1114–20. doi:10.1016/j.lfs.2005.06.021. PMID 16154161.
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