Norsalsolinol

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Norsalsolinol
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Names
Preferred IUPAC name
1,2,3,4-Tetrahydroisoquinoline-6,7-diol
Other names
6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
Identifiers
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3D model (JSmol)
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  • InChI=1S/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2 ☒N
    Key: MBFUSGLXKQWVDW-UHFFFAOYSA-N ☒N
  • InChI=1/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2
    Key: MBFUSGLXKQWVDW-UHFFFAOYAF
  • C1CNCC2=CC(=C(C=C21)O)O
Properties
C9H11NO2
Molar mass 165.189 g/mol
Hazards
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Norsalsolinol is a tetrahydroisoquinoline that is produced naturally in the body through the metabolism of dopamine.[1] It has been shown to be a selective dopaminergic neurotoxin,[2][3][4] and has been suggested as a possible cause of neurodegenerative conditions such as Parkinson's disease and the brain damage associated with alcoholism,[5][6] although evidence for a causal relationship is unclear.[7][8][9]

The related compound (R)-salsolinol, which has been shown to be a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake in rats.[10]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Maruyama W, Takahashi T, Minami M, Takahashi A, Dostert P, Nagatsu T, Naoi M (1993). "Cytotoxicity of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines". Advances in Neurology. 60: 224–30. PMID 8093579.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Maruyama Y, Suzuki Y, Kazusaka A, Fujita S (May 2001). "Norsalsolinol uptake into secretory vesicles via vesicular monoamine transporter and its secretion by membrane depolarization or purinoceptor stimulation in PC12 cells". The Journal of Veterinary Medical Science. 63 (5): 493–7. doi:10.1292/jvms.63.493. PMID 11411492.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Maruyama Y, Suzuki Y, Kazusaka A, Fujita S (June 2001). "Uptake of the dopaminergic neurotoxin, norsalsolinol, into PC12 cells via dopamine transporter". Archives of Toxicology. 75 (4): 209–13. Bibcode:2001ArTox..75..209M. doi:10.1007/s002040000202. PMID 11482518. S2CID 38150947.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Kobayashi H, Fukuhara K, Tada-Oikawa S, Yada Y, Hiraku Y, Murata M, Oikawa S (January 2009). "The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease". Journal of Neurochemistry. 108 (2): 397–407. doi:10.1111/j.1471-4159.2008.05774.x. PMID 19012744.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Dostert P, Strolin Benedetti M, Della Vedova F, Allievi C, La Croix R, Dordain G, Vernay D, Durif F (1993). "Dopamine-derived tetrahydroisoquinolines and Parkinson's disease". Advances in Neurology. 60: 218–23. PMID 8420138.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Musshoff F, Daldrup T, Bonte W, Leitner A, Lesch OM (October 1997). "Salsolinol and norsalsolinol in human urine samples". Pharmacology Biochemistry and Behavior. 58 (2): 545–50. doi:10.1016/S0091-3057(97)00251-7. PMID 9300617. S2CID 76761.
  7. ^ Page Module:Citation/CS1/styles.css has no content.Musshoff F, Lachenmeier DW, Kroener L, Schmidt P, Dettmeyer R, Madea B (July 2003). "Simultaneous gas chromatographic-mass spectrometric determination of dopamine, norsalsolinol and salsolinol enantiomers in brain samples of a large human collective". Cellular and Molecular Biology (Noisy-le-Grand, France). 49 (5): 837–49. PMID 14528920.
  8. ^ Page Module:Citation/CS1/styles.css has no content.Scholz J, Klingemann I, Moser A (April 2004). "Increased systemic levels of norsalsolinol derivatives are induced by levodopa treatment and do not represent biological markers of Parkinson's disease". Journal of Neurology, Neurosurgery, and Psychiatry. 75 (4): 634–6. doi:10.1136/jnnp.2003.010769. PMC 1739023. PMID 15026514.
  9. ^ Page Module:Citation/CS1/styles.css has no content.Musshoff F, Lachenmeier DW, Schmidt P, Dettmeyer R, Madea B (January 2005). "Systematic regional study of dopamine, norsalsolinol, and (R/S)-salsolinol levels in human brain areas of alcoholics". Alcoholism: Clinical and Experimental Research. 29 (1): 46–52. doi:10.1097/01.ALC.0000150011.81102.C2. PMID 15654290.
  10. ^ Page Module:Citation/CS1/styles.css has no content."(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. | PubFacts.com". www.pubfacts.com. Retrieved 2017-10-02.

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