PCGF2
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Polycomb group RING finger protein 2, PCGF2, also known as MEL18 or RNF110, is a protein that in humans is encoded by the PCGF2 gene.[1][2]
Function
The protein encoded by this gene contains a RING finger motif. PCGF2 is a component of the canonical PRC1 complex composed of RING1A/B, CBX2/CBX4, polyhomeotic (PHC) proteins and is very similar to the PCGF4/BMI1 containing PRC1.[3][4] Canonical PRC1 binds to chromatin via the chromodomain of the CBX subunit that recognizes the H3K27me3 mark deposited by PRC2.[5][6] Canonical PRC1 complexes have been shown to compact chromatin and mediate higher-order chromatin structures.[7][8][9]
Polycomb complexes maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. PCGF2 was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.[2]
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: PCGF2 polycomb group ring finger 2".
- ^ Page Module:Citation/CS1/styles.css has no content.Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, et al. (February 2012). "PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes". Molecular Cell. 45 (3): 344–56. doi:10.1016/j.molcel.2012.01.002. PMC 3293217. PMID 22325352.
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- ^ Page Module:Citation/CS1/styles.css has no content.Bernstein E, Duncan EM, Masui O, Gil J, Heard E, Allis CD (April 2006). "Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin". Molecular and Cellular Biology. 26 (7): 2560–9. doi:10.1128/MCB.26.7.2560-2569.2006. PMC 1430336. PMID 16537902.
- ^ Page Module:Citation/CS1/styles.css has no content.Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, et al. (November 2002). "Role of histone H3 lysine 27 methylation in Polycomb-group silencing". Science. 298 (5595): 1039–43. Bibcode:2002Sci...298.1039C. doi:10.1126/science.1076997. PMID 12351676. S2CID 6265267.
- ^ Page Module:Citation/CS1/styles.css has no content.Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, et al. (June 2019). "Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression". Molecular Cell. 74 (5): 1020–1036.e8. doi:10.1016/j.molcel.2019.03.024. PMC 6561741. PMID 31029541.
- ^ Page Module:Citation/CS1/styles.css has no content.Blackledge NP, Fursova NA, Kelley JR, Huseyin MK, Feldmann A, Klose RJ (February 2020). "PRC1 Catalytic Activity Is Central to Polycomb System Function". Molecular Cell. 77 (4): 857–874.e9. doi:10.1016/j.molcel.2019.12.001. PMC 7033600. PMID 31883950.
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Further reading
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- Page Module:Citation/CS1/styles.css has no content.Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Page Module:Citation/CS1/styles.css has no content.Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T (August 2001). "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene". Immunity. 15 (2): 275–87. doi:10.1016/S1074-7613(01)00182-0. PMID 11520462.
- Page Module:Citation/CS1/styles.css has no content.Miyazaki K, Inoue H, Onai N, Ishihara H, Kanno M (February 2002). "Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18". Immunology Letters. 80 (2): 139–43. doi:10.1016/S0165-2478(01)00315-7. PMID 11750047.
- Page Module:Citation/CS1/styles.css has no content.Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (September 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Molecular and Cellular Biology. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
- Page Module:Citation/CS1/styles.css has no content.Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H (September 2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. doi:10.1242/dev.129.18.4171. PMID 12183370.
- Page Module:Citation/CS1/styles.css has no content.Matsuo F, Yano K, Saito H, Morotomi K, Kato M, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Miki Y (2002). "Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines". Breast Cancer. 9 (1): 33–8. doi:10.1007/BF02967544. PMID 12196719. S2CID 26605827.
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- Page Module:Citation/CS1/styles.css has no content.Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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