PIK3R2
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.[1][2]
A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.[3]
Interactions
PIK3R2 has been shown to interact with:
- CRKL[4]
- Cbl gene,[5][6]
- Epidermal growth factor,[7]
- FYN,[7]
- HER2/neu,[7]
- Macrophage colony-stimulating factor,[7] and
- PIK3CD.[8]
Clinical relevance
PIK3R2 mutations were recently shown to be associated with polymicrogyria.[9]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, et al. (April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789–793. PMID 1314371.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)".
- ^ Page Module:Citation/CS1/styles.css has no content.Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.
- ^ Page Module:Citation/CS1/styles.css has no content.Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574.
- ^ Page Module:Citation/CS1/styles.css has no content.Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.
- ^ Page Module:Citation/CS1/styles.css has no content.Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144.
- ^ a b c d Page Module:Citation/CS1/styles.css has no content.Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
- ^ Page Module:Citation/CS1/styles.css has no content.Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
- ^ Page Module:Citation/CS1/styles.css has no content.Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, et al. (December 2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". The Lancet. Neurology. 14 (12): 1182–1195. doi:10.1016/S1474-4422(15)00278-1. PMC 4672724. PMID 26520804.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (November 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–682. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
- Page Module:Citation/CS1/styles.css has no content.Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406.
- Page Module:Citation/CS1/styles.css has no content.Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (November 1990). "Purification and characterization of phosphoinositide 3-kinase from rat liver". The Journal of Biological Chemistry. 265 (32): 19704–19711. doi:10.1016/S0021-9258(17)45429-9. PMID 2174051.
- Page Module:Citation/CS1/styles.css has no content.Truitt KE, Hicks CM, Imboden JB (March 1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells". The Journal of Experimental Medicine. 179 (3): 1071–1076. doi:10.1084/jem.179.3.1071. PMC 2191424. PMID 7509360.
- Page Module:Citation/CS1/styles.css has no content.Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". Biochemistry. 34 (17): 5971–5979. doi:10.1021/bi00017a026. PMID 7537096.
- Page Module:Citation/CS1/styles.css has no content.Craparo A, O'Neill TJ, Gustafson TA (June 1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor". The Journal of Biological Chemistry. 270 (26): 15639–15643. doi:10.1074/jbc.270.26.15639. PMID 7541045.
- Page Module:Citation/CS1/styles.css has no content.He W, O'Neill TJ, Gustafson TA (October 1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains". The Journal of Biological Chemistry. 270 (40): 23258–23262. doi:10.1074/jbc.270.40.23258. PMID 7559478.
- Page Module:Citation/CS1/styles.css has no content.Kapeller R, Toker A, Cantley LC, Carpenter CL (October 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry. 270 (43): 25985–25991. doi:10.1074/jbc.270.43.25985. PMID 7592789.
- Page Module:Citation/CS1/styles.css has no content.Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144.
- Page Module:Citation/CS1/styles.css has no content.Pandey A, Lazar DF, Saltiel AR, Dixit VM (December 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of Biological Chemistry. 269 (48): 30154–30157. doi:10.1016/S0021-9258(18)43790-8. PMID 7982920.
- Page Module:Citation/CS1/styles.css has no content.August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology. 6 (5): 769–774. doi:10.1093/intimm/6.5.769. PMID 8080844.
- Page Module:Citation/CS1/styles.css has no content.Fukazawa T, Miyake S, Band V, Band H (June 1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins". The Journal of Biological Chemistry. 271 (24): 14554–14559. doi:10.1074/jbc.271.24.14554. PMID 8662998.
- Page Module:Citation/CS1/styles.css has no content.Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (September 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". The Journal of Biological Chemistry. 271 (38): 22961–22964. doi:10.1074/jbc.271.38.22961. PMID 8798481.
- Page Module:Citation/CS1/styles.css has no content.Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574.
- Page Module:Citation/CS1/styles.css has no content.Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
- Page Module:Citation/CS1/styles.css has no content.Briand G, Barbeau B, Tremblay M (February 1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase". Virology. 228 (2): 171–179. doi:10.1006/viro.1996.8399. PMID 9123823.
- Page Module:Citation/CS1/styles.css has no content.Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, et al. (June 1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site". Oncogene. 14 (22): 2619–2631. doi:10.1038/sj.onc.1201123. PMID 9178760.
- Page Module:Citation/CS1/styles.css has no content.Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, et al. (July 1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle". The Journal of Biological Chemistry. 272 (30): 19000–19007. doi:10.1074/jbc.272.30.19000. PMID 9228082.
- Page Module:Citation/CS1/styles.css has no content.Mazerolles F, Barbat C, Fischer A (September 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology. 27 (9): 2457–2465. doi:10.1002/eji.1830270946. PMID 9341793. S2CID 33397908.
