PIN domain
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| PIN domain | |||||||
|---|---|---|---|---|---|---|---|
| Lua error in package.lua at line 80: module 'Module:InfoboxImage/data' not found. Crystal structure of PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 Angstrom resolution. Template:PDB2 | |||||||
| Identifiers | |||||||
| Symbol | PIN | ||||||
| Pfam | PF01850 | ||||||
| InterPro | IPR002716 | ||||||
| SMART | CBS | ||||||
| SCOP2 | 3dbo / SCOPe / SUPFAM | ||||||
| CDD | cd09852 | ||||||
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In molecular biology the PIN domain is a protein domain that is about 130 amino acids in length. PIN domains function as nuclease enzymes that cleave single stranded RNA in a sequence- or structure-dependent manner.[1][2]
PIN domains contain four nearly invariant acidic residues.[2] Crystal structures show these residues clustered together in the putative active site. In eukaryotes PIN domains are found in proteins involved in nonsense mediated mRNA decay, in proteins such as SMG5 and SMG6, and in processing of 18S ribosomal RNA. The majority of PIN-domain proteins found in prokaryotes are the toxic components of toxin-antitoxin operons.[2] These loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress.[3]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Arcus VL, McKenzie JL, Robson J, Cook GM (January 2011). "The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array". Protein Engineering, Design & Selection. 24 (1–2): 33–40. doi:10.1093/protein/gzq081. PMID 21036780.
- ^ a b c Page Module:Citation/CS1/styles.css has no content.Matelska D, Steczkiewicz K, Ginalski K (July 2017). "Comprehensive classification of the PIN domain-like superfamily". Nucleic Acids Research. 45 (12): 6995–7020. doi:10.1093/nar/gkx494. PMC 5499597. PMID 28575517.
- ^ Page Module:Citation/CS1/styles.css has no content.Gerdes K, Christensen SK, Løbner-Olesen A (May 2005). "Prokaryotic toxin-antitoxin stress response loci". Nature Reviews. Microbiology. 3 (5): 371–82. doi:10.1038/nrmicro1147. PMID 15864262. S2CID 13417307.
