POLR2E
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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.[1]
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.[2]
Interactions
POLR2E has been shown to interact with TAF15,[3] POLR2C,[4] POLR2G,[4] POLR2H,[4] POLR2A,[4] POLR2B,[4] POLR2L[4] and GTF2F2.[5]
References
- ^ Page Module:Citation/CS1/styles.css has no content.Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–499. doi:10.1006/geno.1994.1208. PMID 8034326.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa".
- ^ Page Module:Citation/CS1/styles.css has no content.Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. 18 (3). UNITED STATES: 1489–1497. doi:10.1128/mcb.18.3.1489. ISSN 0270-7306. PMC 108863. PMID 9488465.
- ^ a b c d e f Page Module:Citation/CS1/styles.css has no content.Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (Jul 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27). UNITED STATES: 16815–16821. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.
- ^ Page Module:Citation/CS1/styles.css has no content.Wei W, Dorjsuren D, Lin Y, Qin W, Nomura T, Hayashi N, Murakami S (Apr 2001). "Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II". J. Biol. Chem. 276 (15). United States: 12266–12273. doi:10.1074/jbc.M009634200. ISSN 0021-9258. PMID 11278533.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. Bibcode:1998CBio....8.R447Y. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
- Page Module:Citation/CS1/styles.css has no content.Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–368. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359. S2CID 43685090.
- Page Module:Citation/CS1/styles.css has no content.Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–181. doi:10.1080/152165401753544241. PMID 11547919. S2CID 10931640.
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- Page Module:Citation/CS1/styles.css has no content.Cheong JH, Yi M, Lin Y, Murakami S (1995). "Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation". EMBO J. 14 (1): 143–150. doi:10.1002/j.1460-2075.1995.tb06984.x. PMC 398061. PMID 7828586.
- Page Module:Citation/CS1/styles.css has no content.Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–1620. doi:10.1128/jvi.69.3.1612-1620.1995. PMC 188757. PMID 7853496.
- Page Module:Citation/CS1/styles.css has no content.Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–2510. Bibcode:1996PNAS...93.2505K. doi:10.1073/pnas.93.6.2505. PMC 39827. PMID 8637904.
- Page Module:Citation/CS1/styles.css has no content.Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–4584. doi:10.1128/jvi.70.7.4576-4584.1996. PMC 190394. PMID 8676484.
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