PRRX2
Template:Short description An Error has occurred retrieving Wikidata item for infobox Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.[1][2]
Function
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.[2]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (Mar 2001). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm Genome. 11 (11): 1000–5. doi:10.1007/s003350010193. PMID 11063257. S2CID 9937434.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: PRRX2 paired related homeobox 2".
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Tokutomi Y, Araki N, Kataoka K, et al. (2007). "Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis". Biochem. Biophys. Res. Commun. 364 (4): 822–30. Bibcode:2007BBRC..364..822T. doi:10.1016/j.bbrc.2007.10.095. PMID 17964282.
- Page Module:Citation/CS1/styles.css has no content.Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.
- Page Module:Citation/CS1/styles.css has no content.Gervais C, Mauvieux L, Perrusson N, et al. (2005). "A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia". Leukemia. 19 (1): 145–8. doi:10.1038/sj.leu.2403565. PMID 15496970.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Scott KK, Norris RA, Potter SS, et al. (2003). "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein". DNA Cell Biol. 22 (2): 95–105. doi:10.1089/104454903321515904. PMID 12713735.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Jones FS, McKean DM, Meech R, et al. (2002). "Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes". Chest. 121 (3 Suppl): 89S–90S. doi:10.1378/chest.121.3_suppl.89S-a. PMID 11893718.
- Page Module:Citation/CS1/styles.css has no content.Stelnicki EJ, Arbeit J, Cass DL, et al. (1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". J. Invest. Dermatol. 111 (1): 57–63. doi:10.1046/j.1523-1747.1998.00238.x. PMID 9665387.
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