PTPRF
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene.[1][2]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig-like domains similar to those of the neural cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.[2]
Interactions
PTPRF has been shown to interact with Beta-catenin[3][4] and liprin-alpha-1.[5][6][7]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Harder KW, Saw J, Miki N, Jirik F (Nov 1995). "Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line". Genomics. 27 (3): 552–3. doi:10.1006/geno.1995.1092. PMID 7558042.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: PTPRF protein tyrosine phosphatase, receptor type, F".
- ^ Page Module:Citation/CS1/styles.css has no content.Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, Dunach M, Neckers LM (Feb 2001). "Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Res. 61 (4): 1671–7. PMID 11245482.
- ^ Page Module:Citation/CS1/styles.css has no content.Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (Aug 1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638. PMID 9245795.
- ^ Page Module:Citation/CS1/styles.css has no content.Pulido R, Serra-Pagès C, Tang M, Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.
- ^ Page Module:Citation/CS1/styles.css has no content.Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Jun 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.
- ^ Page Module:Citation/CS1/styles.css has no content.Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Chernoff J (1999). "Protein tyrosine phosphatases as negative regulators of mitogenic signaling". J. Cell. Physiol. 180 (2): 173–81. doi:10.1002/(SICI)1097-4652(199908)180:2<173::AID-JCP5>3.0.CO;2-Y. PMID 10395287. S2CID 24952421.
- Page Module:Citation/CS1/styles.css has no content.Hashimoto N, Feener EP, Zhang WR, Goldstein BJ (1992). "Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain". J. Biol. Chem. 267 (20): 13811–4. doi:10.1016/S0021-9258(19)49639-7. PMID 1321126.
- Page Module:Citation/CS1/styles.css has no content.Jirik FR, Harder KW, Melhado IG, Anderson LL, Duncan AM (1993). "The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin". Cytogenet. Cell Genet. 61 (4): 266–8. doi:10.1159/000133418. PMID 1486801.
- Page Module:Citation/CS1/styles.css has no content.Streuli M, Krueger NX, Thai T, Tang M, Saito H (1990). "Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR". EMBO J. 9 (8): 2399–407. doi:10.1002/j.1460-2075.1990.tb07415.x. PMC 552264. PMID 1695146.
- Page Module:Citation/CS1/styles.css has no content.Streuli M, Krueger NX, Tsai AY, Saito H (1989). "A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8698–702. Bibcode:1989PNAS...86.8698S. doi:10.1073/pnas.86.22.8698. PMC 298355. PMID 2554325.
- Page Module:Citation/CS1/styles.css has no content.Streuli M, Krueger NX, Hall LR, Schlossman SF, Saito H (1988). "A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen". J. Exp. Med. 168 (5): 1523–30. doi:10.1084/jem.168.5.1523. PMC 2189122. PMID 2972792.
- Page Module:Citation/CS1/styles.css has no content.Schaapveld RQ, van den Maagdenberg AM, Schepens JT, Weghuis DO, Geurts van Kessel A, Wieringa B, Hendriks WJ (1995). "The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization". Genomics. 27 (1): 124–30. doi:10.1006/geno.1995.1014. hdl:2066/21329. PMID 7665159.
- Page Module:Citation/CS1/styles.css has no content.Serra-Pagès C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J. 14 (12): 2827–38. doi:10.1002/j.1460-2075.1995.tb07282.x. PMC 398401. PMID 7796809.
- Page Module:Citation/CS1/styles.css has no content.O'Grady P, Krueger NX, Streuli M, Saito H (1994). "Genomic organization of the human LAR protein tyrosine phosphatase gene and alternative splicing in the extracellular fibronectin type-III domains". J. Biol. Chem. 269 (40): 25193–9. doi:10.1016/S0021-9258(17)31516-8. PMID 7929208.
- Page Module:Citation/CS1/styles.css has no content.Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–90. Bibcode:1995PNAS...9211686P. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829.
- Page Module:Citation/CS1/styles.css has no content.Liu X, Vega QC, Decker RA, Pandey A, Worby CA, Dixon JE (1996). "Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities". J. Biol. Chem. 271 (10): 5309–12. doi:10.1074/jbc.271.10.5309. PMID 8621380.
- Page Module:Citation/CS1/styles.css has no content.Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5466–71. Bibcode:1996PNAS...93.5466D. doi:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598.
- Page Module:Citation/CS1/styles.css has no content.Zhang WR, Li PM, Oswald MA, Goldstein BJ (1996). "Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR". Mol. Endocrinol. 10 (5): 575–84. doi:10.1210/mend.10.5.8732688. PMID 8732688. S2CID 42128485.
- Page Module:Citation/CS1/styles.css has no content.Tabiti K, Cui L, Chhatwal VJ, Moochhala S, Ngoi SS, Pallen CJ (1996). "Novel alternative splicing predicts a secreted extracellular isoform of the human receptor-like protein tyrosine phosphatase LAR". Gene. 175 (1–2): 7–13. doi:10.1016/0378-1119(96)00113-8. PMID 8917069.
- Page Module:Citation/CS1/styles.css has no content.Ahmad F, Goldstein BJ (1997). "Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells". J. Biol. Chem. 272 (1): 448–57. doi:10.1074/jbc.272.1.448. PMID 8995282.
- Page Module:Citation/CS1/styles.css has no content.Aicher B, Lerch MM, Müller T, Schilling J, Ullrich A (1997). "Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing". J. Cell Biol. 138 (3): 681–96. doi:10.1083/jcb.138.3.681. PMC 2141638. PMID 9245795.
- Page Module:Citation/CS1/styles.css has no content.Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
- Page Module:Citation/CS1/styles.css has no content.O'Grady P, Thai TC, Saito H (1998). "The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR". J. Cell Biol. 141 (7): 1675–84. doi:10.1083/jcb.141.7.1675. PMC 2133008. PMID 9647658.
- Page Module:Citation/CS1/styles.css has no content.Chiplunkar S, Chamblis K, Chwa M, Rosenberg S, Kenney MC, Brown DJ (1999). "Enhanced expression of a transmembrane phosphotyrosine phosphatase (LAR) in keratoconus cultures and corneas". Exp. Eye Res. 68 (3): 283–93. doi:10.1006/exer.1998.0604. PMID 10079136.
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