Phenacemide

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Phenacemide
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Clinical data
Trade namesPhenurone
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Pharmacokinetic data
Elimination half-life22–25 hours
Identifiers
  • N-Carbamoyl-2-phenyl-acetamide
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Chemical and physical data
FormulaC9H10N2O2
Molar mass178.191 g·mol−1
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  • O=C(NC(=O)N)Cc1ccccc1
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Phenacemide (INN, BAN) (brand name Phenurone), also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class.[1] It is a congener and ring-opened analogue of phenytoin (a hydantoin),[2][3] and is structurally related to the barbiturates and to other hydantoins.[4] Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn due to toxicity.[2][3]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1578–. ISBN 978-0-412-46630-4.
  2. ^ a b Page Module:Citation/CS1/styles.css has no content.Prasad JP (2010). "Central Nervous System". Conceptual Pharmacology. Universities Press. pp. 236–. ISBN 978-81-7371-679-9.
  3. ^ a b Page Module:Citation/CS1/styles.css has no content.Saxena AK, Saxena M (1995). "Developments in anticonvulsants". In deStevens G, Zingel V, Leschke C, Hoeprich P, Schultz R, Mehrotra P, et al. (eds.). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Vol. 44. Basel: Birkhäuser. pp. 185–291. doi:10.1007/978-3-0348-7161-7_6. ISBN 978-3-0348-7161-7. PMID 7644666. {{cite book}}: |journal= ignored (help)
  4. ^ Page Module:Citation/CS1/styles.css has no content.Kadam SS, Mahadik KR, Bothara KG (1 July 2007). "Central Nervous System Depresants". Principles of Medicinal Chemistry. Vol. II. Pragati Books Pvt. Ltd. pp. 147–. ISBN 978-81-85790-03-9.

Further reading

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