Pierre Chambon
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Pierre Chambon (Script error: No such module "IPA".; 7 February 1931 – 5 May 2026) was a French molecular biologist who the founder of the Template:Interlanguage link multi in Strasbourg, France.[1] He was one of the leading molecular biologists who utilized gene cloning and sequencing technology to first decipher the structure of eukaryotic genes and their modes of regulation. His major contributions to science include the identification of RNA polymerase II (B)[nb 1], the identification of transcriptional control elements, the cloning and dissection of nuclear hormone receptors and the revealing of their structure and demonstrating how they contribute to human physiology. His group was also one of the first to demonstrate, biochemically and electron-microscopically, that the nucleosome is the smallest unit of chromatin (Cell, Vol. 4, 281–300, 1975). He accomplished much of his work from the 1970s to the 1990s.
The core of Pierre Chambon's scientific work has been dedicated to the genetics and molecular biology of vertebrates.
1. Discovery of a new polynucleotide, polyADP-ribose (1963)
2. Discovery of the multiplicity of RNA polymerases in eukaryotes (1969)
3. Contribution to the elucidation of the structure of active and inactive chromatin (the nucleosome) (1975)
4. Discovery that histones are responsible for the supercoiling of DNA in chromatin (1975)
5. Discovery of split genes in animal genomes (1977)
6. Characterization of promoter elements of eukaryotic protein-coding genes and discovery of the "enhancer" element (1980-1987)
7. Cloning of estrogen and progesterone receptors; elucidation of the mechanism of action of steroid hormones at the level of gene expression (1985-1990)
8. Discovery of nuclear receptors for retinoids (1987-)
9. Discovery of the nuclear receptor superfamily, their three-dimensional structure, molecular mechanism of action, and their physiological and pathophysiological functions at the cellular and organismal levels (1987-)
10. Discovery of a method allowing somatic mutations to be induced in mice at a chosen time and in a specific tissue or cell type.
Chambon was elected a Foreign Associate of the US National Academy of Sciences and to the French Académie des Sciences in 1985, a foreign member of the Royal Swedish Academy of Sciences in 1987.[2] He was awarded the Louisa Gross Horwitz Prize[3] from Columbia University in 1999 and a second time in 2018. In 2003 he was awarded the March of Dimes Prize in Developmental Biology. He received the Albert Lasker Award for Basic Medical Research in 2004 for his work in the field. In 2010, Chambon was awarded the Gairdner Foundation International Award "for the elucidation of fundamental mechanisms of transcription in animal cells and to the discovery of the nuclear receptor superfamily".[4] He was a founding member of the University of Strasbourg Institute for Advanced Study (USIAS), where he held the permanent Chair of Molecular Genetics and Biology.
Pierre Chambon died in Strasbourg on 5 May 2026, at the age of 95.[5][6][7]
Notes
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- ^ Chambon named his three polymerases A, B, C. The now-more-common designations I, II, III were the nomenclature used by Robert G. Roeder and William J. Rutter.
References
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- ^ Page Module:Citation/CS1/styles.css has no content."Pierre Chambon - USIAS - University of Strasbourg". www.usias.fr (in français). Retrieved 2018-04-30.
- ^ Page Module:Citation/CS1/styles.css has no content."Kungl. Vetenskapsakademien". 2017-11-10. Archived from the original on 2017-11-10. Retrieved 2023-08-11.
- ^ Page Module:Citation/CS1/styles.css has no content."The Louisa Gross Horwitz Prize". Columbia University Irving Medical Center. 2022-11-11. Retrieved 2023-08-11.
- ^ Pierre Chambon, M.D. - The Gairdner Foundation Script error: No such module "webarchive".
- ^ Le Mulhousien Pierre Chambon, sommité de la recherche scientifique, est décédé à 95 ans Template:In lang
- ^ In Memoriam: Professor Pierre Chambon (1931–2026)
- ^ Page Module:Citation/CS1/styles.css has no content."Deuils - Pierre Chambon". Le Figaro (in french). May 12, 2026. Retrieved May 12, 2026.
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External links
- The Official Site of Louisa Gross Horwitz Prize
- ISI Highly Cited page
- Pierre Chambon at IMDbTemplate:Edit at Wikidata
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