RAB27A
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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.[1][2]
Function
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2 and hemophagocytic lymphohistiocytosis. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]
The RAB27A gene is regulated by the Microphthalmia-associated transcription factor.[3][4]
Interactions
RAB27A has been shown to interact with:
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See also
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Seabra MC, Ho YK, Anant JS (Dec 1995). "Deficient geranylgeranylation of Ram/Rab27 in choroideremia". J Biol Chem. 270 (41): 24420–7. doi:10.1074/jbc.270.41.24420. PMID 7592656.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: RAB27A RAB27A, member RAS oncogene family".
- ^ Page Module:Citation/CS1/styles.css has no content.Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, Bahadoran P, Ortonne JP, Bertolotto C, Ballotti R (2008). "Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport". J. Biol. Chem. 283 (18): 12635–42. doi:10.1074/jbc.M800130200. PMID 18281284.
- ^ Page Module:Citation/CS1/styles.css has no content.Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
- ^ a b c Page Module:Citation/CS1/styles.css has no content.Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
- ^ Page Module:Citation/CS1/styles.css has no content.Wu X, Wang F, Rao K, Sellers JR, Hammer JA (May 2002). "Rab27a is an essential component of melanosome receptor for myosin Va". Mol. Biol. Cell. 13 (5): 1735–49. doi:10.1091/mbc.01-12-0595. PMC 111140. PMID 12006666.
- ^ Page Module:Citation/CS1/styles.css has no content.Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (Apr 2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. 517 (1–3): 233–8. Bibcode:2002FEBSL.517..233N. doi:10.1016/s0014-5793(02)02634-0. PMID 12062444.
- ^ Page Module:Citation/CS1/styles.css has no content.Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R (Jan 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.
- ^ Page Module:Citation/CS1/styles.css has no content.Fukuda M (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Fukuda M (Apr 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (Jul 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Nagata K, Itoh H, Katada T, Takenaka K, Ui M, Kaziro Y, Nozawa Y (1989). "Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein". J. Biol. Chem. 264 (29): 17000–5. doi:10.1016/S0021-9258(18)71450-6. PMID 2507536.
- Page Module:Citation/CS1/styles.css has no content.Chen D, Guo J, Miki T, Tachibana M, Gahl WA (1997). "Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets". Biochem. Mol. Med. 60 (1): 27–37. doi:10.1006/bmme.1996.2559. PMID 9066979.
- Page Module:Citation/CS1/styles.css has no content.Tolmachova T, Ramalho JS, Anant JS, Schultz RA, Huxley CM, Seabra MC (1999). "Cloning, mapping and characterization of the human RAB27A gene". Gene. 239 (1): 109–16. doi:10.1016/S0378-1119(99)00371-6. PMID 10571040.
- Page Module:Citation/CS1/styles.css has no content.Ménasché G, Pastural E, Feldmann J, Certain S, Ersoy F, Dupuis S, Wulffraat N, Bianchi D, Fischer A, Le Deist F, de Saint Basile G (2000). "Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome". Nat. Genet. 25 (2): 173–6. doi:10.1038/76024. PMID 10835631. S2CID 7698624.
- Page Module:Citation/CS1/styles.css has no content.Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
- Page Module:Citation/CS1/styles.css has no content.Haddad EK, Wu X, Hammer JA, Henkart PA (2001). "Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice". J. Cell Biol. 152 (4): 835–42. doi:10.1083/jcb.152.4.835. PMC 2195776. PMID 11266473.
- Page Module:Citation/CS1/styles.css has no content.Bahadoran P, Aberdam E, Mantoux F, Buscà R, Bille K, Yalman N, de Saint-Basile G, Casaroli-Marano R, Ortonne JP, Ballotti R (2001). "Rab27a: A key to melanosome transport in human melanocytes". J. Cell Biol. 152 (4): 843–50. doi:10.1083/jcb.152.4.843. PMC 2195788. PMID 11266474.
- Page Module:Citation/CS1/styles.css has no content.Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
- Page Module:Citation/CS1/styles.css has no content.Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
- Page Module:Citation/CS1/styles.css has no content.Fukuda M, Kuroda TS, Mikoshiba K (2002). "Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport". J. Biol. Chem. 277 (14): 12432–6. doi:10.1074/jbc.C200005200. PMID 11856727.
- Page Module:Citation/CS1/styles.css has no content.Yi Z, Yokota H, Torii S, Aoki T, Hosaka M, Zhao S, Takata K, Takeuchi T, Izumi T (2002). "The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules". Mol. Cell. Biol. 22 (6): 1858–67. doi:10.1128/MCB.22.6.1858-1867.2002. PMC 135591. PMID 11865063.
- Page Module:Citation/CS1/styles.css has no content.Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
- Page Module:Citation/CS1/styles.css has no content.Wu X, Wang F, Rao K, Sellers JR, Hammer JA (2002). "Rab27a is an essential component of melanosome receptor for myosin Va". Mol. Biol. Cell. 13 (5): 1735–49. doi:10.1091/mbc.01-12-0595. PMC 111140. PMID 12006666.
- Page Module:Citation/CS1/styles.css has no content.Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains". Biochem. Biophys. Res. Commun. 293 (3): 899–906. Bibcode:2002BBRC..293..899K. doi:10.1016/S0006-291X(02)00320-0. PMID 12051743.
- Page Module:Citation/CS1/styles.css has no content.Anikster Y, Huizing M, Anderson PD, Fitzpatrick DL, Klar A, Gross-Kieselstein E, Berkun Y, Shazberg G, Gahl WA, Hurvitz H (2002). "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A". Am. J. Hum. Genet. 71 (2): 407–14. doi:10.1086/341606. PMC 379173. PMID 12058346.
- Page Module:Citation/CS1/styles.css has no content.Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. 517 (1–3): 233–8. Bibcode:2002FEBSL.517..233N. doi:10.1016/S0014-5793(02)02634-0. PMID 12062444.
- Page Module:Citation/CS1/styles.css has no content.Torii S, Zhao S, Yi Z, Takeuchi T, Izumi T (2002). "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a". Mol. Cell. Biol. 22 (15): 5518–26. doi:10.1128/MCB.22.15.5518-5526.2002. PMC 133943. PMID 12101244.
- Page Module:Citation/CS1/styles.css has no content.Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
- Page Module:Citation/CS1/styles.css has no content.Barral DC, Ramalho JS, Anders R, Hume AN, Knapton HJ, Tolmachova T, Collinson LM, Goulding D, Authi KS, Seabra MC (2002). "Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome". J. Clin. Invest. 110 (2): 247–57. doi:10.1172/JCI15058. PMC 151050. PMID 12122117.
