RNF5
From Wikipedia, the free encyclopedia
Template:Short description An Error has occurred retrieving Wikidata item for infobox E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene.[1][2]
Function
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.[2]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Kyushiki H, Kuga Y, Suzuki M, Takahashi E, Horie M (Apr 1998). "Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans". Cytogenetics and Cell Genetics. 79 (1–2): 114–7. doi:10.1159/000134695. PMID 9533025.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: RNF5 ring finger protein 5".
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Kendall E, Sargent CA, Campbell RD (December 1990). "Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci". Nucleic Acids Research. 18 (24): 7251–7. doi:10.1093/nar/18.24.7251. PMC 332860. PMID 2259622.
- Page Module:Citation/CS1/styles.css has no content.Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Page Module:Citation/CS1/styles.css has no content.Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB (August 2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2". Journal of Cellular Biochemistry. 79 (2): 213–24. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMC 3501957. PMID 10967549.
- Page Module:Citation/CS1/styles.css has no content.Matsuda N, Suzuki T, Tanaka K, Nakano A (May 2001). "Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase". Journal of Cell Science. 114 (Pt 10): 1949–57. doi:10.1242/jcs.114.10.1949. PMID 11329381.
- Page Module:Citation/CS1/styles.css has no content.Pouly S, Prat A, Blain M, Olivier A, Antel J (October 2001). "NG2 immunoreactivity on human brain endothelial cells". Acta Neuropathologica. 102 (4): 313–20. doi:10.1007/s004010000350. PMID 11603805. S2CID 1353236.
- Page Module:Citation/CS1/styles.css has no content.Didier C, Broday L, Bhoumik A, Israeli S, Takahashi S, Nakayama K, Thomas SM, Turner CE, Henderson S, Sabe H, Ronai Z (August 2003). "RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization". Molecular and Cellular Biology. 23 (15): 5331–45. doi:10.1128/MCB.23.15.5331-5345.2003. PMC 165736. PMID 12861019.
- Page Module:Citation/CS1/styles.css has no content.Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (December 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Page Module:Citation/CS1/styles.css has no content.Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Page Module:Citation/CS1/styles.css has no content.Liu AM, Wong YH (December 2004). "G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling" (PDF). The Journal of Biological Chemistry. 279 (51): 53196–204. doi:10.1074/jbc.M410196200. PMID 15485865.
- Page Module:Citation/CS1/styles.css has no content.Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
- Page Module:Citation/CS1/styles.css has no content.Zhang Y, Higashide W, Dai S, Sherman DM, Zhou D (November 2005). "Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1". The Journal of Biological Chemistry. 280 (46): 38682–8. doi:10.1074/jbc.M506309200. PMID 16176924.
- Page Module:Citation/CS1/styles.css has no content.Younger JM, Chen L, Ren HY, Rosser MF, Turnbull EL, Fan CY, Patterson C, Cyr DM (August 2006). "Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator". Cell. 126 (3): 571–82. doi:10.1016/j.cell.2006.06.041. PMID 16901789. S2CID 51698.
- Page Module:Citation/CS1/styles.css has no content.Bromberg KD, Kluger HM, Delaunay A, Abbas S, DiVito KA, Krajewski S, Ronai Z (September 2007). "Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer". Cancer Research. 67 (17): 8172–9. doi:10.1158/0008-5472.CAN-07-0045. PMC 2962863. PMID 17804730.
- Page Module:Citation/CS1/styles.css has no content.Fujita Y, Khateb A, Li Y, Tinoco R, Zhang T, Bar-Yoseph H, Tam MA, Chowers Y, Sabo E, Gerassy-Vainberg S, Starosvetsky E, James B, Brown K, Shen-Orr SS, Bradley LM, Tessier PA, Ronai ZA (September 2018). "Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis". Cell Reports. 24 (12): 3296–3311.e6. doi:10.1016/j.celrep.2018.08.057. PMC 6185744. PMID 30232010.
External links
- RNF5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
