Relugolix

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Relugolix
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Clinical data
Pronunciation/ˌrɛlʊˈɡoʊlɪks/
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Trade namesOrgovyx, Relumina
Other namesRGX; RVT-601; TAK-385
AHFS/Drugs.comMonograph
MedlinePlusa621006
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Routes of
administration		By mouth[1]
Drug classGnRH antagonist
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Legal status
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Pharmacokinetic data
Protein binding68–71%[1]
Elimination half-life36 to 65 hours[1]
ExcretionFeces: 82%[1]
Urine: 4%[1]
Identifiers
  • 1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
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Chemical and physical data
FormulaC29H27F2N7O5S
Molar mass623.64 g·mol−1
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  • CONC(=O)Nc1ccc(-c2sc3c(c2CN(C)C)c(=O)n(-c2ccc(OC)nn2)c(=O)n3Cc2c(F)cccc2F)cc1
  • InChI=1S/C29H27F2N7O5S/c1-36(2)14-19-24-26(39)38(22-12-13-23(42-3)34-33-22)29(41)37(15-18-20(30)6-5-7-21(18)31)27(24)44-25(19)16-8-10-17(11-9-16)32-28(40)35-43-4/h5-13H,14-15H2,1-4H3,(H2,32,35,40)
  • Key:AOMXMOCNKJTRQP-UHFFFAOYSA-N
Data page
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Relugolix, sold under the brand names Orgovyx and Relumina among others, is a gonadotropin-releasing hormone antagonist (GnRH receptor antagonist) medication which is used in the treatment of prostate cancer, uterine fibroids and endometriosis.[5][1][7][8] It is taken by mouth.[1][7]

Side effects of relugolix include menstrual abnormalities, hot flashes, excessive sweating, headache, and decreased bone mineral density.[7][1] Relugolix is a GnRH antagonist, or an antagonist of the gonadotropin-releasing hormone receptor.[1] Unlike most other GnRH modulators, but similarly to elagolix (brand name Orilissa), relugolix is a non-peptide, small-molecule compound and is orally active.[9][10][11] It suppresses sex hormone levels to the postmenopausal or castrate range in both women and men.[1][12][5]

Medical uses

Relugolix is approved in the United States, Canada and the United Kingdom for the treatment of prostate cancer, in Japan for the treatment of uterine fibroids (uterine leiomyoma) and in the United Kingdom for endometriosis.[13][7][5][14][8]

Available forms

Relugolix is available in the form of 40 and 120 mg oral tablets.[5][14][7]

Side effects

The main side effects of relugolix for uterine fibroids include abnormal uterine bleeding (24.6–48.6% vs. 6.3% for placebo), hot flashes (42.8–45.5% vs. 0% for placebo), heavy menstrual bleeding (12.1–49.3% vs. 9.4% for placebo), headache (12.3–15.2%), and excessive sweating (9.4–15.2% vs. 0% for placebo).[1][7] In addition, decreased bone mineral density occurs with relugolix (21.7% decrease by week 12, 24.4% decrease by week 24).[1]

Pharmacology

Pharmacodynamics

File:Estradiol levels with 40 mg per day oral relguolix therapy in premenopausal women.png
Estradiol levels with 40 mg relugolix once per day in premenopausal women relative to untreated premenopausal women.[7]

Relugolix is a selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR), with a half-maximal inhibitory concentration (IC50) of 0.12 nM.[1][9][10]

A dosage of relugolix of 40 mg once per day has been found to suppress estradiol levels to postmenopausal levels (<20 pg/mL) within 24 hours in premenopausal women.[1] In the control group of women, estradiol levels fluctuated between 50 and 250 pg/mL.[1] Estradiol levels have been found to return to normal concentrations within 4 weeks of discontinuation of relugolix in premenopausal women.[1] The medication additionally suppresses levels of progesterone, luteinizing hormone, and follicle-stimulating hormone in premenopausal women.[1] Relugolix at a dosage of 40 mg or more once per day has been found to reduce testosterone levels to sustained castrate levels (<20 ng/dL) in men.[12] It additionally suppresses luteinizing hormone and follicle-stimulating hormone levels in men.[12]

Lower doses of relugolix (<40 mg/day) are under investigation for achieving partial sex hormone suppression in the treatment of endometriosis and uterine fibroids.[15] This is intended to reduce the incidence and severity of menopausal symptoms such as hot flushes and decreased bone mineral density that are secondary to estrogen deficiency.[15][16]

Pharmacokinetics

A single 40-mg oral dose of relugolix has been found to result in peak levels of relugolix of 29 ng/mL (47 nmol/L) after 1.5 hours.[1] Steady-state levels are reached within 7 days with 40 mg/day relugolix administration.[1] There is an approximate 2-fold accumulation of relugolix by 2 weeks of continuous administration.[1] Food diminishes the oral bioavailability of relugolix by about 50%.[1]

Relugolix is a substrate for P-glycoprotein, which may have a limiting effect on its absorption and distribution.[1] The plasma protein binding of relugolix is approximately 68 to 71% over a concentration range of 0.05 to 5 μg/mL.[1]

Relugolix is not a substrate for CYP3A4.[1] The elimination half-life of relugolix is 36 to 65 hours across a dosage range of 20 to 180 mg/day.[1] There is moderate to high interindividual variability in systemic exposure to relugolix.[1]

Relugolix is excreted mainly in feces (83%) and to a small degree in urine (4%).[1] Only about 6% of a dose of relugolix is excreted unchanged.[1]

Chemistry

Relugolix is a non-peptide, small-molecule compound, and is structurally distinct from GnRH analogues.[11] It is an N-phenyl urea derivative.[1]

Synthesis

The discovery route of relugolix was recently reported:[17] A scalable process was also developed recently:[18]

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A Gewald aminothiophene synthesis between 4-nitrophenylacetone [5332-96-7] (1) and ethyl cyanoacetate [105-56-6] (2) in the presence of sulfur and triethylamine to give an aminothiophene [174072-89-0]. The amino group was protected with cathyl chloride to give the corresponding carbamate, [308831-93-8] (3). Alkylation with 2,6-Difluorobenzyl chloride [697-73-4] (4) gave [308831-94-9]. Next, a free-radical bromination gave [308831-95-0] (5). Displacement of the bromide with (2-methoxyethyl)(methyl)amine [38256-93-8] (6) and subsequent catalytic hydrogenation of the nitro group gave PC53388810 (7). The aniline was reacted with CDI, and the resulting imidazolide was further treated with methoxyamine [67-62-9] to give the urea [737789-92-3] (8). A cyclization reaction mediated by diethyl pyrocarbonate (DEPC) in the presence of 3-methoxy-6-aminopyridazine [7252-84-8] (9) followed by exposure to sodium methoxide generated thymine derivative [737789-61-6] (10). Quaternization of the basic amine with 1-chloroethyl chloroformate followed by displacement with dimethylamine completed the synthesis of relugolix (11).

History

Relugolix was first described in 2004.[19][9] It superseded sufugolix (developmental code name TAK-013), which was developed by the same researchers.[9] Relugolix was approved for the treatment of uterine fibroids in Japan in January 2019.[13][14] It was the second orally active GnRH antagonist to be introduced for medical use, following elagolix (brand name Orilissa) in July 2018.[13][20] Relugolix was approved for the treatment of prostate cancer in the United States on 18 December 2020.[13][5]

The FDA approved relugolix based on evidence from a clinical trial (NCT03085095) of 930 participants 48 to 97 years old with advanced prostate cancer.[21] The trial was conducted at 155 sites in the United States, Canada, and countries in South America, Europe and the Asia Pacific region.[21] All participants in the trial had advanced prostate cancer.[21] Participants were randomly assigned to receive either one relugolix tablet daily (on the first day they received three tables) or an active control (leuprolide acetate) which was given as an injection under the skin every three months.[21] The participants and healthcare providers were aware of which treatment was being given.[21] The treatment lasted for 48 weeks.[21] The efficacy of relugolix was assessed by the percentage of participants who achieved and maintained low testosterone level equal to castration.[21]

Society and culture

Names

Relugolix is the generic name of the drug and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, and JANTooltip Japanese Accepted Name.[22][23] It is also known by its former developmental code names RVT-601 and TAK-385.[13][22]

Relugolix is sold under the brand name Orgovyx for the treatment of prostate cancer and under the brand name Relumina for the treatment of uterine fibroids.[13][14][7][5] Relugolix compounded with estradiol hemihydrate and norethindrone is sold under the brand name Myfembree for the treatment of uterine fibroids.[24]

In February 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Orgovyx, intended for the treatment of prostate cancer.[25] The applicant for this medicinal product is Myovant Sciences Ireland Limited.[25] Relugolix was approved for medical use in the European Union in April 2022,[6][26] and in the United Kingdom in July 2022[27] (although not available in NHS England until August 2024[28]).

References

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  1. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac Page Module:Citation/CS1/styles.css has no content.Barra F, Seca M, Della Corte L, Giampaolino P, Ferrero S (August 2019). "Relugolix for the treatment of uterine fibroids". Drugs of Today. 55 (8): 503–512. doi:10.1358/dot.2019.55.8.3020179. PMID 31461087. S2CID 201654739.
  2. ^ Page Module:Citation/CS1/styles.css has no content."Therapeutic Goods (Poisons Standard—June 2024) Instrument 2024". Federal Register of Legislation. 30 May 2024. Retrieved 10 June 2024.
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  4. ^ Page Module:Citation/CS1/styles.css has no content."Summary Basis of Decision (SBD) for Orgovyx". Health Canada. 16 February 2024. Retrieved 24 February 2024.
  5. ^ a b c d e f g Page Module:Citation/CS1/styles.css has no content."Orgovyx- relugolix tablet, film coated". DailyMed. Retrieved 25 May 2021.
  6. ^ a b Page Module:Citation/CS1/styles.css has no content."Orgovyx EPAR". European Medicines Agency. 22 February 2022. Retrieved 3 March 2023. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  7. ^ a b c d e f g h Page Module:Citation/CS1/styles.css has no content."Relumina (relugolix) Information" (PDF). ASKA Pharmaceutical (in 日本語). January 2019. Archived from the original (PDF) on 16 February 2019. Retrieved 16 February 2019.
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  9. ^ a b c d Page Module:Citation/CS1/styles.css has no content.Miwa K, Hitaka T, Imada T, Sasaki S, Yoshimatsu M, Kusaka M, et al. (July 2011). "Discovery of 1-{4-[1-(2,6-difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a potent, orally active, non-peptide antagonist of the human gonadotropin-releasing hormone receptor". Journal of Medicinal Chemistry. 54 (14): 4998–5012. doi:10.1021/jm200216q. PMID 21657270.
  10. ^ a b Page Module:Citation/CS1/styles.css has no content.Nakata D, Masaki T, Tanaka A, Yoshimatsu M, Akinaga Y, Asada M, et al. (January 2014). "Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice". European Journal of Pharmacology. 723: 167–174. doi:10.1016/j.ejphar.2013.12.001. PMID 24333551.
  11. ^ a b Page Module:Citation/CS1/styles.css has no content.Tukun FL, Olberg DE, Riss PJ, Haraldsen I, Kaass A, Klaveness J (December 2017). "Recent Development of Non-Peptide GnRH Antagonists". Molecules. 22 (12): 2188. doi:10.3390/molecules22122188. PMC 6149776. PMID 29232843.
  12. ^ a b c Page Module:Citation/CS1/styles.css has no content.MacLean DB, Shi H, Faessel HM, Saad F (December 2015). "Medical Castration Using the Investigational Oral GnRH Antagonist TAK-385 (Relugolix): Phase 1 Study in Healthy Males". The Journal of Clinical Endocrinology and Metabolism. 100 (12): 4579–4587. doi:10.1210/jc.2015-2770. PMC 4667159. PMID 26502357.
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  16. ^ Page Module:Citation/CS1/styles.css has no content.Struthers RS, Nicholls AJ, Grundy J, Chen T, Jimenez R, Yen SS, Bozigian HP (February 2009). "Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix". The Journal of Clinical Endocrinology and Metabolism. 94 (2): 545–551. doi:10.1210/jc.2008-1695. PMC 2646513. PMID 19033369.
  17. ^ Page Module:Citation/CS1/styles.css has no content.Flick, A. C., Leverett, C. A., Ding, H. X., McInturff, E., Fink, S. J., Mahapatra, S., Carney, D. W., Lindsey, E. A., DeForest, J. C., France, S. P., Berritt, S., Bigi-Botterill, S. V., Gibson, T. S., Liu, Y., O'Donnell, C. J. (8 April 2021). "Synthetic Approaches to the New Drugs Approved during 2019". Journal of Medicinal Chemistry. 64 (7): 3604–3657. doi:10.1021/acs.jmedchem.1c00208.
  18. ^ Page Module:Citation/CS1/styles.css has no content.Wang, X., Luo, Y., Zhang, P., Zhu, X., Liu, X., Chen, Y. (November 2024). "An alternative and scalable synthesis for Relugolix". Tetrahedron. 167 134243. doi:10.1016/j.tet.2024.134243.
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Further reading

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  • Clinical trial number NCT03085095 for "A Study to Evaluate the Safety and Efficacy of Relugolix in Men With Advanced Prostate Cancer (HERO)" at ClinicalTrials.gov

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