SPRY4
From Wikipedia, the free encyclopedia
Template:Short description An Error has occurred retrieving Wikidata item for infobox Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[1][2]
Function
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[2]
Interactions
SPRY4 has been shown to interact with TESK1.[3]
See also
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".
- ^ Page Module:Citation/CS1/styles.css has no content.Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry. 8: 11. doi:10.1186/1471-244X-8-11. PMC 2268687. PMID 18298822.
- Page Module:Citation/CS1/styles.css has no content.Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
- Page Module:Citation/CS1/styles.css has no content.Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate. 66 (6): 613–24. doi:10.1002/pros.20353. PMID 16388505. S2CID 43803094.
- Page Module:Citation/CS1/styles.css has no content.Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L52-9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
- Page Module:Citation/CS1/styles.css has no content.Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32. doi:10.1038/ncb978. PMID 12717443. S2CID 33846459.
- Page Module:Citation/CS1/styles.css has no content.Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)
