SRSF2
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene.[1][2][3] MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.[4]
Interactions
SFRS2 has been shown to interact with CDC5L[5] and ASF/SF2.[6]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, et al. (September 1995). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–79. doi:10.1006/geno.1995.1216. PMID 8530103.
- ^ Page Module:Citation/CS1/styles.css has no content.Fu XD, Maniatis T (April 1992). "Isolation of a complementary DNA that encodes the mammalian splicing factor SC35". Science. 256 (5056): 535–538. Bibcode:1992Sci...256..535F. doi:10.1126/science.1373910. PMID 1373910.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2".
- ^ Page Module:Citation/CS1/styles.css has no content.Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M, et al. (October 2022). "Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms". Leukemia. 36 (10): 2499–2508. doi:10.1038/s41375-022-01672-4. PMID 35941213. S2CID 251408524.
- ^ Page Module:Citation/CS1/styles.css has no content.Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–6581. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
- ^ Page Module:Citation/CS1/styles.css has no content.Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–5408. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Sureau A, Soret J, Vellard M, Crochet J, Perbal B (December 1992). "The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene". Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 11683–11687. Bibcode:1992PNAS...8911683S. doi:10.1073/pnas.89.24.11683. PMC 50620. PMID 1465383.
- Page Module:Citation/CS1/styles.css has no content.Vellard M, Sureau A, Soret J, Martinerie C, Perbal B (April 1992). "A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 2511–2515. Bibcode:1992PNAS...89.2511V. doi:10.1073/pnas.89.7.2511. PMC 48691. PMID 1557353.
- Page Module:Citation/CS1/styles.css has no content.Zahler AM, Lane WS, Stolk JA, Roth MB (May 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes & Development. 6 (5): 837–847. doi:10.1101/gad.6.5.837. PMID 1577277.
- Page Module:Citation/CS1/styles.css has no content.DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP (January 1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system". Molecular and Cellular Biology. 7 (1): 379–387. doi:10.1128/mcb.7.1.379. PMC 365079. PMID 3031469.
- Page Module:Citation/CS1/styles.css has no content.Tacke R, Manley JL (July 1995). "The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities". The EMBO Journal. 14 (14): 3540–3551. doi:10.1002/j.1460-2075.1995.tb07360.x. PMC 394422. PMID 7543047.
- Page Module:Citation/CS1/styles.css has no content.Luznik L, Martone ME, Kraus G, Zhang Y, Xu Y, Ellisman MH, Wong-Staal F (July 1995). "Localization of human immunodeficiency virus Rev in transfected and virus-infected cells". AIDS Research and Human Retroviruses. 11 (7): 795–804. doi:10.1089/aid.1995.11.795. PMID 7546906. S2CID 24916512.
- Page Module:Citation/CS1/styles.css has no content.Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Page Module:Citation/CS1/styles.css has no content.Kohtz JD, Jamison SF, Will CL, Zuo P, Lührmann R, Garcia-Blanco MA, Manley JL (March 1994). "Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors". Nature. 368 (6467): 119–124. Bibcode:1994Natur.368..119K. doi:10.1038/368119a0. PMID 8139654. S2CID 4283089.
- Page Module:Citation/CS1/styles.css has no content.Wu JY, Maniatis T (December 1993). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing". Cell. 75 (6): 1061–1070. doi:10.1016/0092-8674(93)90316-I. PMID 8261509. S2CID 22951690.
- Page Module:Citation/CS1/styles.css has no content.Sureau A, Perbal B (February 1994). "Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor". Proceedings of the National Academy of Sciences of the United States of America. 91 (3): 932–936. Bibcode:1994PNAS...91..932S. doi:10.1073/pnas.91.3.932. PMC 521427. PMID 8302870.
- Page Module:Citation/CS1/styles.css has no content.Fu XD (September 1993). "Specific commitment of different pre-mRNAs to splicing by single SR proteins". Nature. 365 (6441): 82–85. Bibcode:1993Natur.365...82F. doi:10.1038/365082a0. PMID 8361546. S2CID 4332012.
- Page Module:Citation/CS1/styles.css has no content.Zhang WJ, Wu JY (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Molecular and Cellular Biology. 16 (10): 5400–5408. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.
- Page Module:Citation/CS1/styles.css has no content.Tronchère H, Wang J, Fu XD (July 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. Bibcode:1997Natur.388..397T. doi:10.1038/41137. PMID 9237760. S2CID 4386808.
- Page Module:Citation/CS1/styles.css has no content.Sureau A, Soret J, Guyon C, Gaillard C, Dumon S, Keller M, et al. (November 1997). "Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene". Nucleic Acids Research. 25 (22): 4513–4522. doi:10.1093/nar/25.22.4513. PMC 147067. PMID 9358160.
- Page Module:Citation/CS1/styles.css has no content.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Page Module:Citation/CS1/styles.css has no content.Zhang WJ, Wu JY (February 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Molecular and Cellular Biology. 18 (2): 676–684. doi:10.1128/mcb.18.2.676. PMC 108778. PMID 9447963.
- Page Module:Citation/CS1/styles.css has no content.Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T (January 1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Research. Molecular Brain Research. 53 (1–2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID 9473574.
- Page Module:Citation/CS1/styles.css has no content.Parfenov VN, Davis DS, Pochukalina GN, Kostyuchek D, Murti KG (April 1998). "Dynamics of distribution of splicing components relative to the transcriptional state of human oocytes from antral follicles". Journal of Cellular Biochemistry. 69 (1): 72–80. doi:10.1002/(SICI)1097-4644(19980401)69:1<72::AID-JCB8>3.0.CO;2-S. PMID 9513048. S2CID 29105448.
