SSX1
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Template:Cs1 config Template:Short description An Error has occurred retrieving Wikidata item for infobox Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.[1][2]
The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.[2]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A (Oct 1995). "Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas". Hum Mol Genet. 4 (6): 1097–9. doi:10.1093/hmg/4.6.1097. PMID 7655467.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1".
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Crew AJ, Clark J, Fisher C, et al. (1995). "Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma". EMBO J. 14 (10): 2333–40. doi:10.1002/j.1460-2075.1995.tb07228.x. PMC 398342. PMID 7539744.
- Page Module:Citation/CS1/styles.css has no content.Clark J, Rocques PJ, Crew AJ, et al. (1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nat. Genet. 7 (4): 502–8. doi:10.1038/ng0894-502. PMID 7951320. S2CID 20503729.
- Page Module:Citation/CS1/styles.css has no content.Sinke RJ, de Leeuw B, Janssen HA, et al. (1993). "Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints". Hum. Genet. 92 (3): 305–8. doi:10.1007/BF00244478. PMID 8406438. S2CID 12442743.
- Page Module:Citation/CS1/styles.css has no content.Chand A, Clark J, Cooper CS, Craig IW (1997). "Long-range organization of reiterated sequences, including the SSX1 cDNA at the OATL1 cluster in Xp11.23". Genomics. 30 (3): 545–52. doi:10.1006/geno.1995.1275. PMID 8825641.
- Page Module:Citation/CS1/styles.css has no content.Thaete C, Brett D, Monaghan P, et al. (1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Hum. Mol. Genet. 8 (4): 585–91. doi:10.1093/hmg/8.4.585. PMID 10072425.
- Page Module:Citation/CS1/styles.css has no content.Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. hdl:2066/170683. PMID 11734557.
- Page Module:Citation/CS1/styles.css has no content.de Bruijn DR, dos Santos NR, Kater-Baats E, et al. (2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes Chromosomes Cancer. 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189. S2CID 11734893.
- Page Module:Citation/CS1/styles.css has no content.Yang K, Lui WO, Xie Y, et al. (2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi:10.1038/sj.onc.1205569. PMID 12037676. S2CID 33515965.
- Page Module:Citation/CS1/styles.css has no content.Güre AO, Wei IJ, Old LJ, Chen YT (2002). "The SSX gene family: characterization of 9 complete genes". Int. J. Cancer. 101 (5): 448–53. doi:10.1002/ijc.10634. PMID 12216073. S2CID 21174312.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Storlazzi CT, Mertens F, Mandahl N, et al. (2003). "A novel fusion gene, SS18L1/SSX1, in synovial sarcoma". Genes Chromosomes Cancer. 37 (2): 195–200. doi:10.1002/gcc.10210. PMID 12696068. S2CID 40041616.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Tvrdík D, Povýsil C, Svatosová J, Dundr P (2005). "Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue". Med. Sci. Monit. 11 (3): MT1–7. PMID 15735574.
- Page Module:Citation/CS1/styles.css has no content.Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Page Module:Citation/CS1/styles.css has no content.Fernebro J, Francis P, Edén P, et al. (2006). "Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma". Int. J. Cancer. 118 (5): 1165–72. doi:10.1002/ijc.21475. PMID 16152617.
- Page Module:Citation/CS1/styles.css has no content.Sun Y, Gao D, Liu Y, et al. (2006). "IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1". Oncogene. 25 (7): 1042–52. doi:10.1038/sj.onc.1209143. PMID 16247461.
