STX1A

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(Redirected from Syntaxin 1A)

Template:Short description An Error has occurred retrieving Wikidata item for infobox Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.[1]

Function

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process.

Syntaxin-1A is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.[2]

Clinical significance

Syntaxins serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis.[3]

The expression level of STX1A is directly correlated with intelligence in Williams syndrome.[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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Nicotine Activity on Dopaminergic Neurons edit
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  1. ^ The interactive pathway map can be edited at WikiPathways: Page Module:Citation/CS1/styles.css has no content."NicotineDopaminergic_WP1602".

Interactions

STX1A has been shown to interact with:

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See also

References

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  2. ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: STX1A syntaxin 1A (brain)".
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Further reading

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