T-complex 1
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Template:Short description An Error has occurred retrieving Wikidata item for infobox T-complex protein 1 or T-complex protein 1 subunit alpha, abbreviated TCP1 or TCP-1,[a] is a protein that in humans is encoded by the TCP1 gene.[1][2][3]
Function
This protein is a member of TRiC (CCT) complex, which is a molecular chaperone and the chaperonin of eukaryotic cells. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[3]
Interactions
TCP1 has been shown to interact with PPP4C[4][5] and HDAC3.[6] TRiC directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates TRiC from LOX-1.[7]
Notes
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References
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- ^ Page Module:Citation/CS1/styles.css has no content.Fonatsch C, Gradl G, Ragoussis J, Ziegler A (Oct 1987). "Assignment of the TCP1 locus to the long arm of human chromosome 6 by in situ hybridization". Cytogenet Cell Genet. 45 (2): 109–12. doi:10.1159/000132439. PMID 3476253.
- ^ Page Module:Citation/CS1/styles.css has no content.Willison K, Kelly A, Dudley K, Goodfellow P, Spurr N, Groves V, Gorman P, Sheer D, Trowsdale J (Nov 1987). "The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region". EMBO J. 6 (7): 1967–74. doi:10.1002/j.1460-2075.1987.tb02459.x. PMC 553584. PMID 3653076.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: TCP1 t-complex 1".
- ^ Page Module:Citation/CS1/styles.css has no content.Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4". J. Biol. Chem. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
- ^ Page Module:Citation/CS1/styles.css has no content.Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell. Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
- ^ Page Module:Citation/CS1/styles.css has no content.Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA (Dec 2002). "Assembly of the SMRT–histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735.
- ^ Page Module:Citation/CS1/styles.css has no content.Bakthavatsalam D, Soung RH, Tweardy DJ, Chiu W, Dixon RA, Woodside DG (Jun 2014). "Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor". FEBS Lett. 588 (13): 2133–40. doi:10.1016/j.febslet.2014.04.049. PMC 4100626. PMID 24846140.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Horwich AL, Willison KR (1993). "Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1". Philos. Trans. R. Soc. Lond. B Biol. Sci. 339 (1289): 313–25, discussion 325–6. doi:10.1098/rstb.1993.0030. PMID 8098536.
- Page Module:Citation/CS1/styles.css has no content.Burston SG, Clarke AR (1997). "Molecular chaperones: physical and mechanistic properties". Essays Biochem. 29: 125–36. PMID 9189717.
- Page Module:Citation/CS1/styles.css has no content.Blanché H, Wright LG, Vergnaud G, de Gouyon B, Lauthier V, Silver LM, Dausset J, Cann HM, Spielman RS (1992). "Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG". Genomics. 12 (4): 826–8. doi:10.1016/0888-7543(92)90317-L. PMID 1572657.
- Page Module:Citation/CS1/styles.css has no content.Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
- Page Module:Citation/CS1/styles.css has no content.Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H (1992). "TCP1 complex is a molecular chaperone in tubulin biogenesis". Nature. 358 (6383): 245–8. Bibcode:1992Natur.358..245Y. doi:10.1038/358245a0. PMID 1630491. S2CID 4287521.
- Page Module:Citation/CS1/styles.css has no content.Lewis VA, Hynes GM, Zheng D, Saibil H, Willison K (1992). "T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol". Nature. 358 (6383): 249–52. Bibcode:1992Natur.358..249L. doi:10.1038/358249a0. PMID 1630492. S2CID 4306360.
- Page Module:Citation/CS1/styles.css has no content.Ursic D, Culbertson MR (1991). "The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes". Mol. Cell. Biol. 11 (5): 2629–40. doi:10.1128/mcb.11.5.2629. PMC 360032. PMID 1901944.
- Page Module:Citation/CS1/styles.css has no content.Kirchhoff C, Willison K (1990). "Nucleotide and amino-acid sequence of human testis-derived TCP1". Nucleic Acids Res. 18 (14): 4247. doi:10.1093/nar/18.14.4247. PMC 331189. PMID 2377466.
- Page Module:Citation/CS1/styles.css has no content.Roobol A, Holmes FE, Hayes NV, Baines AJ, Carden MJ (1995). "Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells". J. Cell Sci. 108 (4): 1477–88. doi:10.1242/jcs.108.4.1477. PMID 7615668.
- Page Module:Citation/CS1/styles.css has no content.Ashworth A (1994). "Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes". Genomics. 18 (2): 195–8. doi:10.1006/geno.1993.1454. PMID 7904580.
- Page Module:Citation/CS1/styles.css has no content.Miklos D, Caplan S, Mertens D, Hynes G, Pitluk Z, Kashi Y, Harrison-Lavoie K, Stevenson S, Brown C, Barrell B (1994). "Primary structure and function of a second essential member of the heterooligomeric TCP1 chaperonin complex of yeast, TCP1 beta". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2743–7. Bibcode:1994PNAS...91.2743M. doi:10.1073/pnas.91.7.2743. PMC 43446. PMID 7908441.
- Page Module:Citation/CS1/styles.css has no content.Chen X, Sullivan DS, Huffaker TC (1994). "Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9111–5. Bibcode:1994PNAS...91.9111C. doi:10.1073/pnas.91.19.9111. PMC 44757. PMID 7916460.
- Page Module:Citation/CS1/styles.css has no content.Kubota H, Hynes G, Carne A, Ashworth A, Willison K (1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Curr. Biol. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530. S2CID 31300131.
- Page Module:Citation/CS1/styles.css has no content.Frydman J, Hartl FU (1996). "Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms". Science. 272 (5267): 1497–502. Bibcode:1996Sci...272.1497F. doi:10.1126/science.272.5267.1497. PMID 8633246. S2CID 22363826.
- Page Module:Citation/CS1/styles.css has no content.Moudjou M, Bordes N, Paintrand M, Bornens M (1996). "gamma-Tubulin in mammalian cells: the centrosomal and the cytosolic forms". J. Cell Sci. 109 (4): 875–87. doi:10.1242/jcs.109.4.875. PMID 8718679.
- Page Module:Citation/CS1/styles.css has no content.Morrison K, Papapetrou C, Attwood J, Hol F, Lynch SA, Sampath A, Hamel B, Burn J, Sowden J, Stott D, Mariman E, Edwards YH (1997). "Genetic mapping of the human homologue (T) of mouse T(Brachyury) and a search for allele association between human T and spina bifida". Hum. Mol. Genet. 5 (5): 669–74. doi:10.1093/hmg/5.5.669. hdl:2066/23945. PMID 8733136.
- Page Module:Citation/CS1/styles.css has no content.Masuno M, Fukao T, Song XQ, Yamaguchi S, Orii T, Kondo N, Imaizumi K, Kuroki Y (1997). "Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26". Genomics. 36 (1): 217–8. doi:10.1006/geno.1996.0452. PMID 8812443.
