TEP1
From Wikipedia, the free encyclopedia
Template:Short description An Error has occurred retrieving Wikidata item for infobox Telomerase protein component 1 is a ncRNA binding protein that in humans is encoded by the TEP1 gene.[1][2]
Function
This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.[2] It is also a minor vault protein.
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (November 1997). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: TEP1 telomerase-associated protein 1".
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Joly EC, Tremblay E, Tanguay RM, Wu Y, Bibor-Hardy V (October 1994). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix". Journal of Cell Science. 107 ( Pt 10) (10): 2851–9. doi:10.1242/jcs.107.10.2851. PMID 7876352.
- Page Module:Citation/CS1/styles.css has no content.Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO (February 1997). "A mammalian telomerase-associated protein". Science. 275 (5302): 973–7. doi:10.1126/science.275.5302.973. PMID 9020079. S2CID 21631570.
- Page Module:Citation/CS1/styles.css has no content.Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO (December 1997). "Human telomerase contains evolutionarily conserved catalytic and structural subunits". Genes & Development. 11 (23): 3109–15. doi:10.1101/gad.11.23.3109. PMC 316744. PMID 9389643.
- Page Module:Citation/CS1/styles.css has no content.Li H, Zhao L, Yang Z, Funder JW, Liu JP (December 1998). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells". The Journal of Biological Chemistry. 273 (50): 33436–42. doi:10.1074/jbc.273.50.33436. PMID 9837921.
- Page Module:Citation/CS1/styles.css has no content.Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (November 1999). "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828.
- Page Module:Citation/CS1/styles.css has no content.Li H, Cao Y, Berndt MC, Funder JW, Liu JP (November 1999). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene. 18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID 10597287.
- Page Module:Citation/CS1/styles.css has no content.Koyanagi Y, Kobayashi D, Yajima T, Asanuma K, Kimura T, Sato T, Kida T, Yagihashi A, Kameshima H, Watanabe N (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Research. 20 (2A): 773–8. PMID 10810353.
- Page Module:Citation/CS1/styles.css has no content.Beattie TL, Zhou W, Robinson MO, Harrington L (October 2000). "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding". Molecular Biology of the Cell. 11 (10): 3329–40. doi:10.1091/mbc.11.10.3329. PMC 14995. PMID 11029039.
- Page Module:Citation/CS1/styles.css has no content.Zhang RG, Zhang RP, Wang XW, Xie H (March 2002). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Research. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411.
- Page Module:Citation/CS1/styles.css has no content.Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ (July 2002). "Differential regulation of telomerase activity by six telomerase subunits". European Journal of Biochemistry. 269 (14): 3442–50. doi:10.1046/j.1432-1033.2002.03025.x. PMID 12135483.
- Page Module:Citation/CS1/styles.css has no content.Zhou JH, Zhang HM, Chen Q, Han DD, Pei F, Zhang LS, Yang DT (August 2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World Journal of Gastroenterology. 9 (8): 1808–14. doi:10.3748/wjg.v9.i8.1808. PMC 4611549. PMID 12918126.
- Page Module:Citation/CS1/styles.css has no content.Li C, Wu MY, Liang YR, Wu XY (November 2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World Journal of Gastroenterology. 9 (11): 2395–9. doi:10.3748/wjg.v9.i11.2395. PMC 4656508. PMID 14606063.
- Page Module:Citation/CS1/styles.css has no content.Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
