TOP2A
Template:Short description An Error has occurred retrieving Wikidata item for infobox DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene.
Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several chemotherapy agents[1] and a variety of mutations in this gene have been associated with the development of drug resistance.[citation needed] Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.[2]
Interactions
TOP2A has been shown to interact with SMURF2,[3] HDAC1,[4][5] CDC5L,[6] Small ubiquitin-related modifier 1,[7] P53,[8] and TOPBP1.[9]
In other species
In Drosophila Hadlaczky et al 1988 found DNA topoisomerase II α to correlate with cell proliferation - but β did not.[10]
See also
- Topoisomerase II
- TOP2B - Topoisomerase II beta
- Gene duplication
- Ataxia-telangiectasia
- TOPBP1
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Deweese, J. E.; Osheroff, N. (2009-02-01). "The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing". Nucleic Acids Research. 37 (3): 738–748. doi:10.1093/nar/gkn937. ISSN 0305-1048. PMC 2647315. PMID 19042970.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: TOP2A topoisomerase (DNA) II alpha 170kDa".
- ^ Page Module:Citation/CS1/styles.css has no content.Emanuelli A, Borroni AP, Apel-Sarid L, Shah PA, Ayyathan DM, Koganti P, et al. (August 2017). "Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity". Cancer Research. 77 (16): 4217–4227. doi:10.1158/0008-5472.CAN-16-2828. PMID 28611047.
- ^ Page Module:Citation/CS1/styles.css has no content.Tsai SC, Valkov N, Yang WM, Gump J, Sullivan D, Seto E (November 2000). "Histone deacetylase interacts directly with DNA topoisomerase II". Nature Genetics. 26 (3): 349–353. doi:10.1038/81671. PMID 11062478. S2CID 19301396.
- ^ Page Module:Citation/CS1/styles.css has no content.Johnson CA, Padget K, Austin CA, Turner BM (February 2001). "Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis". The Journal of Biological Chemistry. 276 (7): 4539–4542. doi:10.1074/jbc.C000824200. PMID 11136718.
- ^ Page Module:Citation/CS1/styles.css has no content.Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–6581. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
- ^ Page Module:Citation/CS1/styles.css has no content.Mao Y, Desai SD, Liu LF (August 2000). "SUMO-1 conjugation to human DNA topoisomerase II isozymes". The Journal of Biological Chemistry. 275 (34): 26066–26073. doi:10.1074/jbc.M001831200. PMID 10862613.
- ^ Page Module:Citation/CS1/styles.css has no content.Cowell IG, Okorokov AL, Cutts SA, Padget K, Bell M, Milner J, Austin CA (February 2000). "Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53". Experimental Cell Research. 255 (1): 86–94. doi:10.1006/excr.1999.4772. PMID 10666337.
- ^ Page Module:Citation/CS1/styles.css has no content.Broderick, Ronan; Niedzwiedz, Wojciech (2015-08-12). "Sister chromatid decatenation: bridging the gaps in our knowledge". Cell Cycle. 14 (19): 3040–3044. doi:10.1080/15384101.2015.1078039. ISSN 1538-4101. PMC 4825568. PMID 26266709.
- ^ Page Module:Citation/CS1/styles.css has no content.Wang JC (1996). "DNA topoisomerases". Annual Review of Biochemistry. 65 (1). Annual Reviews: 635–692. doi:10.1146/annurev.bi.65.070196.003223. PMID 8811192.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681. PMC 1137600. PMID 7980433.
- Page Module:Citation/CS1/styles.css has no content.Bronner C, Hopfner R, Mousli M (2002). "Transcriptional regulation of the human topoisomerase IIalpha gene". Anticancer Research. 22 (2A): 605–612. PMID 12014628.
- Page Module:Citation/CS1/styles.css has no content.Järvinen TA, Liu ET (December 2003). "Topoisomerase IIalpha gene (TOP2A) amplification and deletion in cancer--more common than anticipated". Cytopathology. 14 (6): 309–313. doi:10.1046/j.0956-5507.2003.00105.x. PMID 14632727. S2CID 29586255.
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