TRIB2
Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene.[1][2][3][4] TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing very low vestigial catalytic output in vitro and critical scaffolding signaling functions in cells.[5] It is known to signal to canonical MAPK and AKT pathways and to regulate the ubiquitination of substrates with important functions in cell proliferation that control the cell cycle. It has also been associated with various diseases, especially in human and murine blood and solid tumor models.[6] Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target,[7] and its three dimensional structure has been solved with the aid of stabilizing nanobodies [8] corroborating the potential for new approaches for drug targeting outside the highly degraded ATP site [9] and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation.[10] Recent work has established a convincing link between targetable overexpression of TRIB2 and prostate cancer drug responses [11]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Wu M, Xu LG, Zhai Z, Shu HB (Jul 2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription". J Biol Chem. 278 (29): 27072–9. doi:10.1074/jbc.M209814200. PMID 12736262.
- ^ Page Module:Citation/CS1/styles.css has no content.Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS (Nov 2006). "Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia". Cancer Cell. 10 (5): 401–11. doi:10.1016/j.ccr.2006.09.012. PMC 2839500. PMID 17097562.
- ^ Page Module:Citation/CS1/styles.css has no content.Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci. 63 (14): 1632–41. doi:10.1007/s00018-006-6007-9. PMC 11136108. PMID 16715410. S2CID 24556931.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: TRIB2 tribbles homolog 2 (Drosophila)".
- ^ Page Module:Citation/CS1/styles.css has no content.Bailey FP, et al. (2015). "The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylate very weakly in a metal-independent manner". Biochemical Society Transactions. 467 (1): 47–62. doi:10.1042/BJ20141441. PMC 4844368. PMID 25583260.
- ^ Page Module:Citation/CS1/styles.css has no content.Eyers PA, Keeshan K, Kannan N (2016). "Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease". Trends in Cell Biology. 27 (9): S0962-8924(16)30178-7. doi:10.1016/j.tcb.2016.11.002. PMC 5382568. PMID 27908682.
- ^ Page Module:Citation/CS1/styles.css has no content.Foulkes DM, Byrne DP, Eyers PA (2015). "Tribbles pseudokinases: novel targets for chemical biology and drug discovery?". Biochemical Society Transactions. 43 (5): 1095–1103. doi:10.1042/BST20150109. PMID 26517930.
- ^ Page Module:Citation/CS1/styles.css has no content.Jamieson SA, Pudjihartono M, Horne CR, Viloria JS, Dunlop JL, McMillan HD, Day RC, Keeshan K, Murphy JM, Mace PD (2022). "Nanobodies identify an activated state of the TRIB2 pseudokinase". Structure. 30 (11): 1518–1529. doi:10.1016/j.str.2022.08.006. PMID 36108635.
- ^ Page Module:Citation/CS1/styles.css has no content.Byrne DP, Foulkes DM, Eyers PA (2017). "Pseudokinases: update on their functions and evaluation as new drug targets". Future Medicinal Chemistry. 9 (2): 245–265. doi:10.4155/fmc-2016-0207. PMID 28097887.
- ^ Page Module:Citation/CS1/styles.css has no content.Foulkes DM, Byrne DP, Yeun W, Shrestha S, Bailey FP, Ferries S, Eyers CE, Keeshan K, Wells C, Drewry DH, Zuercher WJ, Kannan N, Eyers PA (2018). "Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells". Science Signaling. 11 (549) eaat7951: 14687. doi:10.1126/scisignal.aat7951. PMC 6553640. PMID 30254057.
- ^ Page Module:Citation/CS1/styles.css has no content.Monga J, Valeriote F, Hwang C, Gadgeel S, Ghosh J (2023). "Daclatasvir, an Antiviral Drug, Downregulates Tribbles 2 Pseudokinase and Resensitizes Enzalutamide-Resistant Prostate Cancer Cells". Molecular Cancer Therapeutics. 22 (3): 381–392. doi:10.1158/1535-7163.mct-21-1002. PMID 36805730.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Kiss-Toth E, Bagstaff SM, Sung HY, et al. (2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades" (PDF). J. Biol. Chem. 279 (41): 42703–8. doi:10.1074/jbc.M407732200. PMID 15299019. S2CID 25829757.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Page Module:Citation/CS1/styles.css has no content.Zhang Y, Davis JL, Li W (2005). "Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display". Mol. Immunol. 42 (11): 1275–81. doi:10.1016/j.molimm.2004.11.020. PMID 15950723.
- Page Module:Citation/CS1/styles.css has no content.Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Page Module:Citation/CS1/styles.css has no content.Lin KR, Lee SF, Hung CM, et al. (2007). "Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway". J. Biol. Chem. 282 (30): 21962–72. doi:10.1074/jbc.M701663200. PMID 17545167.
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