Terizidone

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Terizidone
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Clinical data
Trade namesTerivalidin
Other names4-[({4-[N-(3-oxo-1,2-oxazolidin-4-yl)carboximidoyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
AHFS/Drugs.comInternational Drug Names
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Identifiers
  • 4,4'-{1,4-phenylenebis[(E)methylylidene
    (E)azanylylidene]}bis(1,2-oxazolidin-3-one)
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Chemical and physical data
FormulaC14H14N4O4
Molar mass302.290 g·mol−1
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Terizidone is a drug used in the treatment of tuberculosis.[1] Terizidone is mainly used in multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is a derivative of cycloserine with bacteriostatic activity.[2]

Terizidone is a therapeutic alternative on the World Health Organization's List of Essential Medicines.[3]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Galietti F, Giorgis GE, Oliaro A, Boaro D, Ardizzi A, Barberis S, et al. (1991). "[Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]". Minerva Medica. 82 (7–8): 477–81. PMID 1922892.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Rossiter D (2012). South African Medicines Formulary. Cape Town, South Africa: Health and Medical Publishing Group of the South African Medical Association. pp. 323–325. ISBN 978-1-875098-28-6.
  3. ^ Page Module:Citation/CS1/styles.css has no content.World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. doi:10.2471/B09474. hdl:10665/382243.

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