Thiram

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Thiram
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Names
Preferred IUPAC name
Dimethylcarbamothioic dithioperoxyanhydride
Identifiers
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3D model (JSmol)
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  • InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3 ☒N
    Key: KUAZQDVKQLNFPE-UHFFFAOYSA-N ☒N
  • InChI=1/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3
    Key: KUAZQDVKQLNFPE-UHFFFAOYAK
  • CN(C)C(=S)SSC(=S)N(C)C
Properties
C6H12N2S4
Molar mass 240.42 g·mol−1
Appearance White to yellow crystalline powder
Odor Characteristic[<span title="Script error: No such module "decodeEncode".">vague][1]
Density 1.29 g/cm3[1]
Melting point 155 to 156 °C (311 to 313 °F; 428 to 429 K)
Boiling point decomposes[1]
30 mg/L
Vapor pressure 0.000008 mmHg (20 °C)[1]
Pharmacology
P03AA05 (WHO)
Hazards
Flash point 138 °C (280 °F)[2]
Lethal dose or concentration (LD, LC):
1350 mg/kg (mouse, oral)
210 mg/kg (rabbit, oral)
560 mg/kg (rat, oral)[3]
500 mg/m3 (rat, 4 hr)[3]
NIOSH (US health exposure limits):
PEL (Permissible)
 TWA 5 mg/m3[1]
REL (Recommended)
 TWA 5 mg/m3[1]
IDLH (Immediate danger)
 100 mg/m3[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Template:Chembox Footer/trackingTemplate:Short description

Thiram is an organosulfur compound that is used as a fungicide.[4][5] It is used as a fungicide, ectoparasiticide to prevent fungal diseases in seed and crops and similarly as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents and deer. It is effective against Stem gall of coriander, damping off, smut of millet, neck rot of onion, etc. Thiram has been used in the treatment of human scabies, as a sun screen and as a bactericide applied directly to the skin or incorporated into soap.[6]

Thiram is also used as a sulfur source and secondary accelerator the sulfur vulcanization of rubbers.

Usage

File:Thiram USA 2012.png
Map of agricultural use in the U.S. (2012)

Thiram was traditionally used in apple and wine farming. Since 2010 most thiram is applied to soybeans.

It is registered for use in India.[7]

Chemical properties

Thiram is classified as a thiuram disulfide, which are compounds with the functional group]] N-C(S)-S-S-C(S)-N. Specifically thiram is the oxidized dimer of dimethyldithiocarbamate.[8]

Page Module:Chem2/styles.css has no content.2 (CH3)2NCS2Na + H2O2 → (CH3)2NCS2−SC(S)N(CH3)2 + 2 NaOH

It soluble in chloroform, acetone, and ether. The pure compound is a white solid. Many other thiuram disulfides are available. Commercial samples, which can appear off-white, are available as dust, flowable, wettable powder, water-dispersible granules, and water suspension formulations and in mixtures with other fungicides.[6]

Thiram is nearly immobile in clay soils or in soils of high organic matter. It is not expected to contaminate groundwater because of its in-soil half life of 15 days, in addition to its tendency to adhere to soil particles.[9]

As a waste, thiram carries an U.S. EPA U244 code.

Toxicity

Thiram is moderately toxic by ingestion, but it is highly toxic if inhaled. Acute exposure in humans may cause headaches, dizziness, fatigue, nausea, diarrhea, and other gastrointestinal complaints.[10]

Chronic or repeated exposure may cause sensitive skin, and it may have effects on the thyroid or liver.[11]

References

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  1. ^ a b c d e f g Page Module:Citation/CS1/styles.css has no content.NIOSH Pocket Guide to Chemical Hazards. "#0612". National Institute for Occupational Safety and Health (NIOSH).
  2. ^ U.S. Department of Agriculture, Soil Conservation Service. 1990 (Nov). SCS/ARS/CES Pesticide Properties Database: Version 2.0 (Summary). USDA - Soil Conservation Service, Syracuse, NY.
  3. ^ a b Page Module:Citation/CS1/styles.css has no content."Thiram". Immediately Dangerous to Life or Health Concentrations. National Institute for Occupational Safety and Health.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Thind, Tarlochan S.; Hollomon, Derek W. (2018). "Thiocarbamate fungicides: Reliable tools in resistance management and future outlook". Pest Management Science. 74 (7): 1547–1551. doi:10.1002/ps.4844. PMID 29286551.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Sharma, Vaneet Kumar; Aulakh, J. S.; Malik, Ashok Kumar (2003). "Thiram: Degradation, applications and analytical methods". Journal of Environmental Monitoring. 5 (5): 717–723. doi:10.1039/b304710e. PMID 14587840.
  6. ^ a b Page Module:Citation/CS1/styles.css has no content."Thiram". Extension Toxicology Network.
  7. ^ Page Module:Citation/CS1/styles.css has no content.Paranjape, Kalyani; Gowariker, Vasant; Krishnamurthy, V.N.; Gowariker, Sudha (2015). The Pesticide Encyclopedia. CABI. ISBN 978-1-78064-014-3.
  8. ^ Page Module:Citation/CS1/styles.css has no content.Schubart, Rüdiger (2026). "Dithiocarbamic Acid and Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. pp. 1–28. doi:10.1002/14356007.a09_001.pub2. ISBN 978-3-527-30385-4.
  9. ^ Page Module:Citation/CS1/styles.css has no content.Howard, P.H., ed. (1989). Handbook of Environmental Fate and Exposure Data for Organic Chemicals. Vol. III: Pesticides. Chelsea, MI: Lewis Publishers.
  10. ^ Page Module:Citation/CS1/styles.css has no content.Hayes, W.J. and E.R. Laws, ed. (1990). Handbook of Pesticide Toxicology. Vol. 3, Classes of Pesticides. NY: Academic Press, Inc.
  11. ^ NIOSH - Thiram International Chemical Safety Card (ICSC July 22, 2015
  • Thiram in the Pesticide Properties DataBase (PPDB)

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