Udenafil

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Udenafil
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Clinical data
Routes of
administration		By mouth
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Legal status
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Pharmacokinetic data
Protein binding93,9%
MetabolismLiver (mainly CYP3A4)
Elimination half-life7.3–12.1 hours
ExcretionBiliary
Identifiers
  • 3-(1-Methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide
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Chemical and physical data
FormulaC25H36N6O4S
Molar mass516.66 g·mol−1
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  • O=C2\N=C(/Nc1c(nn(c12)C)CCC)c3cc(ccc3OCCC)S(=O)(=O)NCCC4N(C)CCC4
  • InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32) checkY
  • Key:IYFNEFQTYQPVOC-UHFFFAOYSA-N checkY
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The drug udenafil is marketed under the trade name Zydena. It is within the PDE5 inhibitor class (which also includes avanafil, sildenafil, tadalafil, and vardenafil). Like other PDE5 inhibitors, it is used to treat erectile dysfunction. Udenafil was developed by Dong-A Pharmaceutical.[1] It has fairly rapid onset of action (peak plasma concentration after 1 to 1.5 hours), and has long duration of action (plasma half-life of 11 to 13 hours). Udenafil's pharmacokinetics allows once-daily dosage (in addition to on-demand use).[2] Typical doses are 100 and 200 mg. Udenafil is available in Korea, Russia, and the Philippines.[3] It has not yet been approved for use in the United States by the U.S. Food and Drug Administration.

References

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  1. ^ Zydena (udenafil) product-information page. Dong-A Pharmaceutical. Retrieved on April 13, 2009.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Kang SG, Kim JJ (April 2013). "Udenafil: efficacy and tolerability in the management of erectile dysfunction". Therapeutic Advances in Urology. 5 (2): 101–10. doi:10.1177/1756287212470019. PMC 3607490. PMID 23554845.
  3. ^ Page Module:Citation/CS1/styles.css has no content."Zydena". Drugs.com.

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