Voglibose
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| Formula | C10H21NO7 |
| Molar mass | 267.278 g·mol−1 |
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Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering postprandial blood glucose levels in people with diabetes mellitus.[1] Voglibose is a research product of Takeda Pharmaceutical Company, Japan's largest pharmaceutical company. Voglibose was discovered in 1981, and was first launched in Japan in 1994,[2] under the trade name BASEN, to improve postprandial hyperglycemia in diabetes mellitus.[3]
Postprandial hyperglycemia (PPHG) is primarily due to first phase insulin secretion. Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal.[2]
There are three major drugs which belong to this class, acarbose, miglitol and voglibose,[2] of which voglibose is the newest.
Efficacy
A Cochrane systematic review assessed the effect of alpha-glucosidase inhibitors (acarbose and voglibose) in people with impaired glucose tolerance, impaired fasting blood glucose, elevated glycated hemoglobin A1c (HbA1c).[4] Trials of people diagnosed with “metabolic syndrome” or such with an intervention duration of less than one year were excluded from this systematic review.
The authors concluded that “[i]n people with intermediate hyperglycaemia the use of alpha‐glucosidase inhibitors [including voglibose] reduces or delays the incidence of type 2 diabetes mellitus”, but “[t]here is no firm evidence that alpha‐glucosidase inhibitors prevent cardiovascular mortality and morbidity.” The results of this review are overall rather uncertain because of “systematic errors in some of the included trials, the overall low number of trials for a particular outcome, imprecise results and missing data of one included trial [“EDIT 1997”, which investigated acarbose, not voglibose].”[4]
The authors investigated in total two studies on voglibose, one which compared it to placebo, one which compared it to diet plus exercise. While the latter one was criticized for imprecision, in the first one, the amount of patients developing diabetes mellitus type 2 was reduced by more than 50% in patients treated with voglibose (5.6%) compared to those treated with placebo (12%). However, this was classified as “low‐certainty evidence”. The two studies where inconclusive for other outcome measures (including all-cause and cardiovascular mortality, non‐fatal myocardial infarction, non‐fatal stroke, congestive heart failure, serious and non‐serious adverse events (increased “non‐serious side effects” where concluded only for acarbose), hypoglycaemia, measures of blood glucose control, blood lipids, body weight, and blood pressure).[4]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Chen X, Zheng Y, Shen Y (2006). "Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors". Current Medicinal Chemistry. 13 (1): 109–116. doi:10.2174/092986706789803035. PMID 16457643.
- ^ a b c Page Module:Citation/CS1/styles.css has no content.Dabhi AS, Bhatt NR, Shah MJ (December 2013). "Voglibose: an alpha glucosidase inhibitor". Journal of Clinical and Diagnostic Research. 7 (12): 3023–3027. doi:10.7860/JCDR/2013/6373.3838. PMC 3919386. PMID 24551718.
- ^ Page Module:Citation/CS1/styles.css has no content."Voglibose". AdisInsight. Springer Nature Switzerland AG.
- ^ a b c Page Module:Citation/CS1/styles.css has no content.Moelands SV, Lucassen PL, Akkermans RP, De Grauw WJ, Van de Laar FA, et al. (Cochrane Metabolic and Endocrine Disorders Group) (December 2018). "Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 2018 (12) CD005061. doi:10.1002/14651858.CD005061.pub3. PMC 6517235. PMID 30592787.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Miller CK (2004). "New therapeutic options in the treatment of diabetes mellitus". In Greenstein B (ed.). Clinical Pharmacology for nurses (17th ed.). Elsevier Limited, Churchill Livingstone.
- Page Module:Citation/CS1/styles.css has no content.Wilson L (1997). Mehra IV (ed.). Managing the Patient with Type II Diabetes. Aspen Publishers. pp. 62–63. ISBN 978-0-8342-1018-9.
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