WASF1
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An Error has occurred retrieving Wikidata item for infobox Wiskott–Aldrich syndrome protein family member 1, also known as WASP-family verprolin homologous protein 1 (WAVE1), is a protein that in humans is encoded by the WASF1 gene.[1][2][3]
Function
The protein encoded by this gene, a member of the Wiskott–Aldrich syndrome protein (WASP) family, plays a critical role downstream of Rac, a Rho-family small GTPase, through its involvement in the WAVE regulatory complex in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro.
Clinical significance
Wiskott–Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton.[3]
Interactions
WASF1 has been shown to interact with BAIAP2[4] and Profilin 1.[1]
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content.Miki H, Suetsugu S, Takenawa T (February 1999). "WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac". EMBO J. 17 (23): 6932–41. doi:10.1093/emboj/17.23.6932. PMC 1171041. PMID 9843499.
- ^ Page Module:Citation/CS1/styles.css has no content.Machesky LM, Insall RH (March 1999). "Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex". Curr Biol. 8 (25): 1347–56. doi:10.1016/S0960-9822(98)00015-3. PMID 9889097. S2CID 16661755.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: WASF1 WAS protein family, member 1".
- ^ Page Module:Citation/CS1/styles.css has no content.Miki H, Yamaguchi H, Suetsugu S, Takenawa T (December 2000). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. 408 (6813): 732–5. Bibcode:2000Natur.408..732M. doi:10.1038/35047107. PMID 11130076. S2CID 4426046.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Sloane JA, Vartanian TK (2007). "WAVE1 and regulation of actin nucleation in myelination". The Neuroscientist. 13 (5): 486–91. doi:10.1177/1073858407299423. PMID 17901257. S2CID 295778.
- Page Module:Citation/CS1/styles.css has no content.Whitebread S, Mele M, Kamber B, de Gasparo M (1989). "Preliminary biochemical characterization of two angiotensin II receptor subtypes". Biochem. Biophys. Res. Commun. 163 (1): 284–91. doi:10.1016/0006-291X(89)92133-5. PMID 2775266.
- Page Module:Citation/CS1/styles.css has no content.Kitamura T, Kitamura Y, Yonezawa K, et al. (1996). "Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck". Biochem. Biophys. Res. Commun. 219 (2): 509–14. doi:10.1006/bbrc.1996.0264. hdl:20.500.14094/D1001555. PMID 8605018.
- Page Module:Citation/CS1/styles.css has no content.Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
- Page Module:Citation/CS1/styles.css has no content.She HY, Rockow S, Tang J, et al. (1997). "Wiskott–Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells". Mol. Biol. Cell. 8 (9): 1709–21. doi:10.1091/mbc.8.9.1709. PMC 305731. PMID 9307968.
- Page Module:Citation/CS1/styles.css has no content.Witke W, Podtelejnikov AV, Di Nardo A, et al. (1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". EMBO J. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMC 1170446. PMID 9463375.
- Page Module:Citation/CS1/styles.css has no content.Bear JE, Rawls JF, Saxe CL (1998). "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development". J. Cell Biol. 142 (5): 1325–35. doi:10.1083/jcb.142.5.1325. PMC 2149354. PMID 9732292.
- Page Module:Citation/CS1/styles.css has no content.Wu Y, Dowbenko D, Lasky LA (1998). "PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase". J. Biol. Chem. 273 (46): 30487–96. doi:10.1074/jbc.273.46.30487. PMID 9804817.
- Page Module:Citation/CS1/styles.css has no content.Suetsugu S, Miki H, Takenawa T (1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem. Biophys. Res. Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
- Page Module:Citation/CS1/styles.css has no content.Banin S, Gout I, Brickell P (1999). "Interaction between Wiskott–Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase". Mol. Biol. Rep. 26 (3): 173–7. doi:10.1023/A:1006954206151. PMID 10532312. S2CID 36018089.
- Page Module:Citation/CS1/styles.css has no content.Higgs HN, Blanchoin L, Pollard TD (1999). "Influence of the C terminus of Wiskott–Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization". Biochemistry. 38 (46): 15212–22. doi:10.1021/bi991843. PMID 10563804.
- Page Module:Citation/CS1/styles.css has no content.Westphal RS, Soderling SH, Alto NM, et al. (2000). "Scar/WAVE-1, a Wiskott–Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold". EMBO J. 19 (17): 4589–600. doi:10.1093/emboj/19.17.4589. PMC 302050. PMID 10970852.
- Page Module:Citation/CS1/styles.css has no content.Prehoda KE, Scott JA, Mullins RD, Lim WA (2000). "Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex". Science. 290 (5492): 801–6. Bibcode:2000Sci...290..801P. doi:10.1126/science.290.5492.801. PMID 11052943.
- Page Module:Citation/CS1/styles.css has no content.Miki H, Yamaguchi H, Suetsugu S, Takenawa T (2001). "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling". Nature. 408 (6813): 732–5. Bibcode:2000Natur.408..732M. doi:10.1038/35047107. PMID 11130076. S2CID 4426046.
- Page Module:Citation/CS1/styles.css has no content.Marchand JB, Kaiser DA, Pollard TD, Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex". Nat. Cell Biol. 3 (1): 76–82. doi:10.1038/35050590. PMID 11146629. S2CID 30437883.
- Page Module:Citation/CS1/styles.css has no content.Eden S, Rohatgi R, Podtelejnikov AV, et al. (2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. Bibcode:2002Natur.418..790E. doi:10.1038/nature00859. PMID 12181570. S2CID 4350733.
- Page Module:Citation/CS1/styles.css has no content.Yarar D, D'Alessio JA, Jeng RL, Welch MD (2003). "Motility determinants in WASP family proteins". Mol. Biol. Cell. 13 (11): 4045–59. doi:10.1091/mbc.E02-05-0294. PMC 133613. PMID 12429845.
- Page Module:Citation/CS1/styles.css has no content.Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388. S2CID 1423222.
